{"id":23165,"date":"2024-05-23T16:16:55","date_gmt":"2024-05-23T10:46:55","guid":{"rendered":"https:\/\/johnsonfrancis.org\/general\/?p=23165"},"modified":"2025-03-06T11:34:41","modified_gmt":"2025-03-06T06:04:41","slug":"severe-hypertriglyceridemia-and-multiorgan-disease","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/general\/severe-hypertriglyceridemia-and-multiorgan-disease\/","title":{"rendered":"Severe Hypertriglyceridemia and Multiorgan Disease"},"content":{"rendered":"

It is well known that severe hypertriglyceridemia with serum triglyceride levels 500 mg\/dL or more is an important risk factor for acute pancreatitis. Severe hypertriglyceridemia is also a risk factor for atherosclerotic cardiovascular disease [1]. New targets for treatment of severe hypertriglyceridemia are inhibition of apolipoprotein C-III, angiopoietin-like protein 3, angiopoietin-like protein 4, and fibroblast growth factor-21. A research letter published in JACC Advances <\/em>estimated the prevalence of chronic conditions and multiorgan disease among adults in the United States of America with severe hypertriglyceridemia [2]. They pooled data from Nutrition Examination Survey of 1999-2000 and 2017-2020 cycles with severe hypertriglyceridemia.<\/p>\n

The chronic conditions included central obesity, diabetes mellitus, chronic kidney disease, metabolic dysfunction-associated steatotic liver disease and history of atherosclerotic cardiovascular disease. As per the data, 2.3 million US adults had severe hypertriglyceridemia. Among those with severe hypertriglyceridemia, 70.3% had central obesity, 32.7% had diabetes, 21.6% had chronic kidney disease, 67% had metabolic dysfunction-associated steatotic liver disease and 10.6% had atherosclerotic cardiovascular disease. Prevalence ratio of chronic conditions was almost three times compared to those with serum triglyceride level below 200 mg\/dL.<\/p>\n

References<\/span><\/strong><\/p>\n

    \n
  1. Malick WA, Do R, Rosenson RS. Severe hypertriglyceridemia: Existing and emerging therapies<\/a>. Pharmacol Ther. 2023 Nov;251:108544. doi: 10.1016\/j.pharmthera.2023.108544. Epub 2023 Oct 15. PMID: 37848164.<\/li>\n
  2. Chen Gurevitz, Ligong Chen, Paul Muntner, and Robert S. Rosenson. Hypertriglyceridemia and Multiorgan Disease Among U.S. Adults<\/a>. JACC Adv. 2024 May, 3 (5) 100932.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    It is well known that severe hypertriglyceridemia with serum triglyceride levels 500 mg\/dL or more is an important risk factor for acute pancreatitis. Severe hypertriglyceridemia is also a risk factor for atherosclerotic cardiovascular disease [1]. New targets for treatment of severe hypertriglyceridemia are inhibition of apolipoprotein C-III, angiopoietin-like protein 3, angiopoietin-like protein 4, and fibroblast […]<\/p>\n","protected":false},"author":1,"featured_media":23172,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[7],"tags":[],"class_list":["post-23165","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"\nSevere Hypertriglyceridemia and Multiorgan Disease - All About Heart And Blood Vessels<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/general\/severe-hypertriglyceridemia-and-multiorgan-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Severe Hypertriglyceridemia and Multiorgan Disease - All About Heart And Blood Vessels\" \/>\n<meta property=\"og:description\" content=\"It is well known that severe hypertriglyceridemia with serum triglyceride levels 500 mg\/dL or more is an important risk factor for acute pancreatitis. Severe hypertriglyceridemia is also a risk factor for atherosclerotic cardiovascular disease [1]. 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