Atherogenic dyslipidemia

Atherogenic dyslipidemia

Atherogenic dyslipidemia is a triad of:

1. Increased blood concentrations of small dense LDL (low density lipoprotein) particles (LDL-P)
2. Decreased HDL (high density lipoprotein) particles (HDL-P)
3. Increased triglyceride rich lipoproteins

Atherogenic dyslipidemia has been linked with coronary artery disease and cerebrovascular disease. Lipoprotein particles are measured using nuclear magnetic resonance (NMR) spectroscopy.

Though low density lipoprotein cholesterol (LDL-C) levels have a strong and consistent association with coronary artery disease and cerebrovascular disease, such association with peripheral arterial disease (PAD) is not so robust. It has been shown that NMR derived measurement of LDL-P correlates with incident PAD [1].

Reference

1. Aday AW, Lawler PR, Cook NR, Ridker PM, Mora S, Pradhan AD. Lipoprotein Particle Profiles, Standard Lipids, and Peripheral Artery Disease Incidence. Prospective Data From the Women’s Health Study.  Circulation. 2018;138:2330–2341.