Brugada Syndrome 1,2,3,4,5,6,7,8

Brugada syndrome (BrS) is an inherited arrhythmogenic syndrome with life threatening ventricular arrhythmias, right bundle branch like pattern and ST segment elevation in right precordial leads. The first gene abnormality to be described was in SCN5A, the sodium channel gene. This has been designated as Brugada syndrome 1. BrS 2 was described as defect in the GPD1L gene. The genetic defect in BrS 3 is localized to the calcium channel gene CACNA1C. BrS 4 has an abnormality in another calcium channel gene CACNB2. BrS 5 has sodium channel gene defect n SCN1B. Potassium channel KCNE3 is defective in BrS 6. Sodium channel SCN3B is defective in BrS 7. HCN4 defect characterises BrS 8.
Reference

  1. Brugada R, Campuzano O, Brugada P, et al. Brugada Syndrome. 2005 Mar 31 [Updated 2014 Apr 10]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1517/

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