Coronary artery disease risk locus on chromosome 9p21
Coronary artery disease risk locus on chromosome 9p21: Chromosome 9p21 single nucleotide polymorphisms (SNPs) have been associated with risk for coronary artery disease. Transcripts EU741058 and NR_003529 of annotated antisense non-coding RNA in the INK4 locus (ANRIL) are involved in the risk of coronary artery disease. The association of chromosome 9p21 and coronary artery disease has been shown several independent populations. A study published in by Christopher Newton-Cheh, Nancy R Cook, Martin VanDenburgh, Eric B Rimm, Paul M Ridker and Christine M Albert [1] prospectively evaluated the risk of development of sudden cardiac death as well. They determined genotypes for rs10757274 for 492 sudden and/or arrhythmic deaths and 1460 matched controls. The age adjusted odds ratio for sudden cardiac death was 1.21 for every copy of the G allele at rs10757274. This study was in persons of European ancestry from six prospective cohort studies.
Another study evaluating perioperative myocardial injury in patients undergoing cardiac surgery also found that common genetic variants on chromosome 9p21 are associated with perioperative myocardial injury. Chromosome 9p21.3 region has also been implicated as a major risk locus in atherosclerotic stroke.
References
- Christopher Newton-Cheh, Nancy R Cook, Martin VanDenburgh, Eric B Rimm, Paul M Ridker, Christine M Albert. A common variant at 9p21 is associated with sudden and arrhythmic cardiac death. Circulation. 2009 Nov 24;120(21):2062-8.