Pathways in pathogenesis of PAH – Cardiology MCQ – Answer
Which of the following is NOT a pathway involved in the pathogenesis of pulmonary arterial hypertension (PAH)?
Correct answer: 4. Pentose phosphate pathway
All the other three are important pathways in the pathogenesis of PAH. Medications used in the treatment block these pathways.
- Endothelin pathway blockers: Bosentan, Ambrisentan, Macitentan
- Nitric oxide pathway: Sildenafil, Tadalafil, Vardenafil (Phosphodiesterase 5 – PDE5 inhibitors)
- Prostacyclin pathway: Epoprostenol, Iloprost, Treprostinil, Beraprost (Prostacyclin analogues) and Selexipag (Selective IP receptor agonist). IP receptor is short for Prostaglandin I2 receptor or prostacyclin receptor.