Reversible and irreversible platelet inhibition by anti platelet agents
Agents which irreversibly inhibit platelets are:
- Aspirin
- Ticlopidine
- Clopidogrel
- Prasugrel
In general all these agents except prasugrel are ideally discontinued 5 days prior to intended surgery. Prasugrel is better discontinued 7 days prior, because of slightly different pharmacodynamics profile.
Agents which reversibly inhibit platelets are:
- Dipyridamole
- Cilostazol
- Nonsteroidal anti-inflammatory drugs
- Ticagrelor