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The 3 Most Common ECG Confusions: Pacing Spikes, Artifact, and LBBB Mimics

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In the world of clinical ECG interpretation, things are rarely as neat as they look in textbooks. Small deviations in morphology or external interference can lead to misdiagnosis, potentially resulting in unnecessary interventions or missed emergencies.

Here is a breakdown of the three most common ECG confusions and how to tell them apart.


1. Pacing Spikes vs. Narrow QRS Complexes

Large unipolar pacemaker spikes can be confused with normal QRS components. Conversely, sharp artifacts can sometimes look like pacing spikes to the untrained eye.


2. Artifact vs. Ventricular Tachycardia (VT)

This is perhaps the most dangerous confusion in a hospital setting. “Toothbrush tachycardia” or patient movement can create waveforms that mimic life-threatening arrhythmias.


3. Left Bundle Branch Block (LBBB) vs. Mimics

LBBB is a classic ECG finding, but several conditions can “mimic” its appearance, leading to incorrect assumptions about heart failure or ischemia.


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