Why is not neprilysin inhibitor used alone?
|In ARNI (Angiotensin receptor blocker+ neprilysin inhibitor), why is ARB (Angiotensin receptor blocker) combined with the neprilysin inhibitor? To be exact, what is the disadvantage of giving neprilysin inhibitor alone?
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Neprilysin degrades all active natriuretic peptides (ANP,BNP, CNP) and also angiotensin II.
If neprilysin inhibitor alone is used, rise in angiotensin II levels will negate its effect by acting on AT1 receptors.
Valsartan blocks the AT1 receptor, hence prevents angiotensin II from exerting its actions.
An important adverse effect of neprilysin inhibitor when used alone?