{"id":10000,"date":"2010-09-30T12:04:03","date_gmt":"2010-09-30T12:04:03","guid":{"rendered":"http:\/\/cardiophile.org\/?p=5341"},"modified":"2023-10-13T11:51:06","modified_gmt":"2023-10-13T06:21:06","slug":"link-between-desmosomes-and-sodium-channel-in-arvc-2","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/link-between-desmosomes-and-sodium-channel-in-arvc-2\/","title":{"rendered":"Link Between Desmosomes and Sodium Channel in ARVC"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/98lERqHHo9s?si=Lt9rr3qkhwGIOYVM\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe><\/p>\n<h2><span style=\"color: #008000;\">Link between desmosomes and sodium channel in ARVC<\/span><\/h2>\n<p>Intercalated discs join the myocardial cells together. Desmosomes and adherens junctions in this region provide mechanical support to the junction. There are also gap junctions which allow transfer of metabolites and electrical impulses between the myocardial cells. Plakophilin-2 (PKP2) is a component of desmosomes and PKP2 mutations are seen in arrhythmogenic right ventricular cardiomyopathy (<a href=\"https:\/\/johnsonfrancis.org\/professional\/arrhythmogenic-rv-dysplasia\/\">ARVC<\/a>). Na<sub>V<\/sub>1.5 the major \u03b1 subunit of the cardiac sodium channel also resides in the intercalated disc.<\/p>\n<p>Sato and colleauges [1] demonstrated in an in-vitro study that the loss of expression of PKP2 leads to decreased peak sodium current and delayed recovery from inactivation of the sodium channels. This leads to a substantial decrease in the sodium current and the conduction velocity. This in turn can lead to conduction block and re-entrant arrhythmias.<\/p>\n<p><span style=\"color: #0000ff;\"><strong>Reference<\/strong><\/span><\/p>\n<ol>\n<li>Priscila Y Sato, Hassan Musa, Wanda Coombs, Guadalupe Guerrero-Serna, Gustavo A Pati\u00f1o, Steven M Taffet, Lori L Isom, Mario Delmar. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19661460\">Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes<\/a>. Circ Res. 2009 Sep 11;105(6):523-6.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Loss of expression of PKP2 decreases peak Na current and delayed recovery from inactivation of Na channels, decreasing Na current and conduction velocity, causing conduction block and re-entrant arrhythmias.<\/p>\n","protected":false},"author":1,"featured_media":36686,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-10000","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ecg-electrophysiology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Link between desmosomes and sodium channel in ARVC<\/title>\n<meta name=\"description\" content=\"Link between desmosomes and sodium channel in ARVC: Loss of expression of PKP2 \u2193 peak Na current and delayed recovery from inactivation of Na channels.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/link-between-desmosomes-and-sodium-channel-in-arvc-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Link between desmosomes and sodium channel in ARVC\" \/>\n<meta property=\"og:description\" content=\"Link between desmosomes and sodium channel in ARVC: Loss of expression of PKP2 \u2193 peak Na current and delayed recovery from inactivation of Na channels.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/link-between-desmosomes-and-sodium-channel-in-arvc-2\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta 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