{"id":10185,"date":"2012-04-22T09:39:25","date_gmt":"2012-04-22T09:39:25","guid":{"rendered":"http:\/\/cardiophile.org\/?p=7005"},"modified":"2012-04-22T09:39:25","modified_gmt":"2012-04-22T09:39:25","slug":"sildenafil-for-pediatric-pulmonary-arterial-hypertension","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/","title":{"rendered":"Sildenafil for pediatric pulmonary arterial hypertension"},"content":{"rendered":"

Sildenafil for pediatric pulmonary arterial hypertension<\/span><\/h2>\n

Sildenafil for pediatric pulmonary arterial hypertension: Barst JR and associates checked in on the role of oral sildenafil citrate in the treatment of pediatric pulmonary arterial hypertension [A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study of Oral Sildenafil Citrate in Treatment-Naive Children with Pulmonary Arterial Hypertension. Circulation. 2012 Jan 17;125(2):324-34<\/a>]. Sildenafil is a phosphodiesterase V (PD5) inhibitor which is known to reduce pulmonary hypertension. Two hundred and thirty five children between the ages of one to seventeen years were enrolled in the STARTS-1<\/strong> trial. It was a randomized placebo controlled trial in in which sildenafil was given orally thrice daily for four months. The main comparison was the effect on peak oxygen consumption (pVO2<\/sub>). Exercise testing was done in one hundred and fifteen of the children. Secondary end points were hemodynamics and functional class. Peak oxygen consumption, functional class and hemodynamics improved in those who were on medium and high doses while the low dose was found to be ineffective. Those who completed STARTS-1 could enter the STARTS-2<\/strong> extension study in which patients already on sildenafil continued it in the same dose while those on placebo were randomized to low, medium or high dose sildenafil as in STARTS-1 study group. In the STARTS-2 study which is ongoing, increased mortality was observed with high dose versus lower dose groups. The authors concluded that with overall combined data, it favours medium dose therapy with sildenafil.<\/p>\n","protected":false},"excerpt":{"rendered":"

Overall combined data favours medium dose therapy with sildenafil for pediatric pulmonary arterial hypertension.<\/p>\n","protected":false},"author":1,"featured_media":39268,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-10185","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"\nSildenafil for pediatric pulmonary arterial hypertension<\/title>\n<meta name=\"description\" content=\"Sildenafil for pediatric pulmonary arterial hypertension: Data favours medium dose therapy with sildenafil for pediatric PAH.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sildenafil for pediatric pulmonary arterial hypertension\" \/>\n<meta property=\"og:description\" content=\"Sildenafil for pediatric pulmonary arterial hypertension: Data favours medium dose therapy with sildenafil for pediatric PAH.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2012-04-22T09:39:25+00:00\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"Sildenafil for pediatric pulmonary arterial hypertension\",\"datePublished\":\"2012-04-22T09:39:25+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/\"},\"wordCount\":242,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"articleSection\":[\"General Cardiology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/\",\"name\":\"Sildenafil for pediatric pulmonary arterial hypertension\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"datePublished\":\"2012-04-22T09:39:25+00:00\",\"description\":\"Sildenafil for pediatric pulmonary arterial hypertension: Data favours medium dose therapy with sildenafil for pediatric PAH.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/#primaryimage\",\"url\":\"\",\"contentUrl\":\"\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Sildenafil for pediatric pulmonary arterial hypertension\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\",\"name\":\"All About Cardiovascular System and Disorders\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\",\"name\":\"Johnson Francis\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"caption\":\"Johnson Francis\"},\"logo\":{\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\"},\"description\":\"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/author\\\/jf\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Sildenafil for pediatric pulmonary arterial hypertension","description":"Sildenafil for pediatric pulmonary arterial hypertension: Data favours medium dose therapy with sildenafil for pediatric PAH.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/","og_locale":"en_US","og_type":"article","og_title":"Sildenafil for pediatric pulmonary arterial hypertension","og_description":"Sildenafil for pediatric pulmonary arterial hypertension: Data favours medium dose therapy with sildenafil for pediatric PAH.","og_url":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/","og_site_name":"All About Cardiovascular System and Disorders","article_published_time":"2012-04-22T09:39:25+00:00","author":"Johnson Francis","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Johnson Francis","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/#article","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/"},"author":{"name":"Johnson Francis","@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"headline":"Sildenafil for pediatric pulmonary arterial hypertension","datePublished":"2012-04-22T09:39:25+00:00","mainEntityOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/"},"wordCount":242,"publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/#primaryimage"},"thumbnailUrl":"","articleSection":["General Cardiology"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/","url":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/","name":"Sildenafil for pediatric pulmonary arterial hypertension","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#website"},"primaryImageOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/#primaryimage"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/#primaryimage"},"thumbnailUrl":"","datePublished":"2012-04-22T09:39:25+00:00","description":"Sildenafil for pediatric pulmonary arterial hypertension: Data favours medium dose therapy with sildenafil for pediatric PAH.","breadcrumb":{"@id":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/#primaryimage","url":"","contentUrl":""},{"@type":"BreadcrumbList","@id":"https:\/\/johnsonfrancis.org\/professional\/sildenafil-for-pediatric-pulmonary-arterial-hypertension\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/johnsonfrancis.org\/professional\/"},{"@type":"ListItem","position":2,"name":"Sildenafil for pediatric pulmonary arterial hypertension"}]},{"@type":"WebSite","@id":"https:\/\/johnsonfrancis.org\/professional\/#website","url":"https:\/\/johnsonfrancis.org\/professional\/","name":"All About Cardiovascular System and Disorders","description":"","publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/johnsonfrancis.org\/professional\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":["Person","Organization"],"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec","name":"Johnson Francis","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","caption":"Johnson Francis"},"logo":{"@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g"},"description":"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal","url":"https:\/\/johnsonfrancis.org\/professional\/author\/jf\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/10185","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/comments?post=10185"}],"version-history":[{"count":0,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/10185\/revisions"}],"wp:attachment":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/media?parent=10185"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/categories?post=10185"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/tags?post=10185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}