{"id":10200,"date":"2012-04-22T11:47:31","date_gmt":"2012-04-22T11:47:31","guid":{"rendered":"http:\/\/cardiophile.org\/?p=7094"},"modified":"2012-04-22T11:47:31","modified_gmt":"2012-04-22T11:47:31","slug":"polymer-free-amphilimus-stent-better-than-paclitaxel-eluting-stent","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/polymer-free-amphilimus-stent-better-than-paclitaxel-eluting-stent\/","title":{"rendered":"Polymer free amphilimus stent better than paclitaxel eluting stent?"},"content":{"rendered":"

Polymer free amphilimus stent better than paclitaxel eluting stent?<\/span><\/h2>\n

Polymer free amphilimus stent better than paclitaxel eluting stent? Didier Carri\u00e9, Jacques Berland, Stefan Verheye, Karl Eugen Hauptmann, Mathias Vrolix, Roberto Violini, Alain Dibie, Sergio Berti, Eric Maupas, David Antoniucci and Joachim Schofer [1] from Europe have compared polymer free amphilimus eluting stents with permanent polymer coated paclitaxel eluting stents in percutaneous coronary interventions of de novo lesions. The primary end point was angiographic late lumen loss at six months. One fifth of the patients had also undergone intravascular ultrasound (IVUS) evaluation. The duration of clinical follow up was five years. Among the three hundred and twenty odd patients studied, the clinical end points of cardiac death, myocardial infarction, target vessel revascularization (TLR) and stent thrombosis was similar between the two groups at one year. In stent late lumen loss was lower with amphilimus stent (0.14 \u00b1 0.36 mm vs. 0.34 \u00b1 0.40 mm, with p for both non inferiority and superiority <0.0001). The authors claim that the polymer free amphilimus stent has a significantly lower in stent late lumen loss and a trend towards better one year clinical safety and efficacy in the treatment of de novo coronary lesions. The stent technology is based on polymer free abluminal reservoir elution which avoids the exposure of the vessel wall to polymers present in the luminal side of conventional drug eluting stents which are potentially proinflammatory and may impair the healing of the vessel. The authors also claim that this feature may potentially reduce the need for prolonged dual antiplatelet therapy with its attendant complications. We need more large scale randomized head to head comparisons of the various new generation coronary stents to get the final answer on which is the better of the lot.<\/p>\n

Reference<\/strong><\/span><\/p>\n

    \n
  1. Didier Carri\u00e9, Jacques Berland, Stefan Verheye, Karl Eugen Hauptmann, Mathias Vrolix, Roberto Violini, Alain Dibie, Sergio Berti, Eric Maupas, David Antoniucci, Joachim Schofer. A Multicenter Randomized Trial Comparing Amphilimus- With Paclitaxel-Eluting Stents in De Novo Native Coronary Artery Lesions.<\/a>\u00a0J Am Coll Cardiol. 2012 Apr 10;59(15):1371-6.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Polymer free amphilimus stent has lower in stent late lumen loss and better 1 year clinical safety and efficacy in treatment of de novo coronary lesions.<\/p>\n","protected":false},"author":1,"featured_media":39305,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[18],"tags":[],"class_list":["post-10200","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-angiography-and-interventions"],"yoast_head":"\nPolymer free amphilimus stent better than paclitaxel eluting stent?<\/title>\n<meta name=\"description\" content=\"Polymer free amphilimus stent better than paclitaxel eluting stent? 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