{"id":11499,"date":"2014-01-08T16:56:07","date_gmt":"2014-01-08T16:56:07","guid":{"rendered":"http:\/\/cardiophile.org\/?p=11499"},"modified":"2014-01-08T16:56:07","modified_gmt":"2014-01-08T16:56:07","slug":"specific-risk-for-bleeding-with-cabg","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/","title":{"rendered":"Specific risk for bleeding with CABG"},"content":{"rendered":"

Specific risk for bleeding with CABG<\/span><\/h2>\n

Specific risk for bleeding with CABG: Coronary artery bypass grafting (CABG) surgery has a few specific factors to it which can cause bleeding:<\/p>\n

    \n
  1. Whole body heparinization therapy<\/li>\n
  2. Platelet dysfunction due to cardiopulmonary bypass pump<\/li>\n
  3. Altered fibrinolysis<\/li>\n<\/ol>\n

    Even though the recommendation is to stop antiplatelet agents 5 days prior to surgery (7 days in case of prasugrel), sometimes surgery may have to be done on an emergency basis. This enhances the chance of perioperative bleeding.<\/p>\n

    A study evaluated the bleeding risk with ticagrelor and clopidogrel [1]. They found that bleeding risk was high if the medications were discontinued less than 24 hours prior to surgery, as occurs in an emergency surgery. Discontinuation 3 days prior to surgery vs 5 days prior to surgery did not increase the risk of bleeding with ticagrelor. But shorter period of discontinuation increased the bleeding risk with clopidogrel. Overall, risk of major bleeding related to CABG was lower with ticagrelor than clopidogrel.<\/p>\n

    Reference<\/span><\/strong><\/p>\n

      \n
    1. Emma C Hansson, Lena Jid\u00e9us, Bengt \u00c5berg Henrik Bjursten, Mats Dreifaldt, Anders Holmgren, Torbj\u00f6rn Ivert, Shahab Nozohoor, Mikael Barbu, Rolf Svedjeholm, Anders Jeppsson. Coronary Artery Bypass Grafting-Related Bleeding Complications in Patients Treated With Ticagrelor or Clopidogrel: A Nationwide Study<\/a>. Eur Heart J. 2016 Jan 7;37(2):189-97.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

      Specific risk for bleeding with CABG Specific risk for bleeding with CABG: Coronary artery bypass grafting (CABG) surgery has a few specific factors to it which can cause bleeding: Whole body heparinization therapy Platelet dysfunction due to cardiopulmonary bypass pump Altered fibrinolysis Even though the recommendation is to stop antiplatelet agents 5 days prior to […]<\/p>\n","protected":false},"author":1,"featured_media":34479,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[22],"tags":[535,911,2905,4241],"class_list":["post-11499","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiac-surgery","tag-bleeding-risk-in-cabg","tag-coronary-artery-bypass-grafting","tag-platelet-dysfunction-due-to-cardiopulmonary-bypass-pump","tag-whole-body-heparinization-therapy"],"yoast_head":"\nSpecific risk for bleeding with CABG: Heparin, platelet dysfunction<\/title>\n<meta name=\"description\" content=\"Specific risk for bleeding with CABG: Whole body heparinization therapy, Platelet dysfunction due to cardiopulmonary bypass pump, Altered fibrinolysis\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Specific risk for bleeding with CABG: Heparin, platelet dysfunction\" \/>\n<meta property=\"og:description\" content=\"Specific risk for bleeding with CABG: Whole body heparinization therapy, Platelet dysfunction due to cardiopulmonary bypass pump, Altered fibrinolysis\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2014-01-08T16:56:07+00:00\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"Specific risk for bleeding with CABG\",\"datePublished\":\"2014-01-08T16:56:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/\"},\"wordCount\":209,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"keywords\":[\"bleeding risk in CABG\",\"Coronary artery bypass grafting\",\"Platelet dysfunction due to cardiopulmonary bypass pump\",\"Whole body heparinization therapy\"],\"articleSection\":[\"Cardiac Surgery\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/\",\"name\":\"Specific risk for bleeding with CABG: Heparin, platelet dysfunction\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"datePublished\":\"2014-01-08T16:56:07+00:00\",\"description\":\"Specific risk for bleeding with CABG: Whole body heparinization therapy, Platelet dysfunction due to cardiopulmonary bypass pump, Altered fibrinolysis\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/#primaryimage\",\"url\":\"\",\"contentUrl\":\"\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/specific-risk-for-bleeding-with-cabg\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Specific risk for bleeding with CABG\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\",\"name\":\"All About Cardiovascular System and Disorders\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\",\"name\":\"Johnson Francis\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"caption\":\"Johnson Francis\"},\"logo\":{\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\"},\"description\":\"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/author\\\/jf\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Specific risk for bleeding with CABG: Heparin, platelet dysfunction","description":"Specific risk for bleeding with CABG: Whole body heparinization therapy, Platelet dysfunction due to cardiopulmonary bypass pump, Altered fibrinolysis","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/","og_locale":"en_US","og_type":"article","og_title":"Specific risk for bleeding with CABG: Heparin, platelet dysfunction","og_description":"Specific risk for bleeding with CABG: Whole body heparinization therapy, Platelet dysfunction due to cardiopulmonary bypass pump, Altered fibrinolysis","og_url":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/","og_site_name":"All About Cardiovascular System and Disorders","article_published_time":"2014-01-08T16:56:07+00:00","author":"Johnson Francis","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Johnson Francis","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/#article","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/"},"author":{"name":"Johnson Francis","@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"headline":"Specific risk for bleeding with CABG","datePublished":"2014-01-08T16:56:07+00:00","mainEntityOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/"},"wordCount":209,"publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/#primaryimage"},"thumbnailUrl":"","keywords":["bleeding risk in CABG","Coronary artery bypass grafting","Platelet dysfunction due to cardiopulmonary bypass pump","Whole body heparinization therapy"],"articleSection":["Cardiac Surgery"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/","url":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/","name":"Specific risk for bleeding with CABG: Heparin, platelet dysfunction","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#website"},"primaryImageOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/#primaryimage"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/#primaryimage"},"thumbnailUrl":"","datePublished":"2014-01-08T16:56:07+00:00","description":"Specific risk for bleeding with CABG: Whole body heparinization therapy, Platelet dysfunction due to cardiopulmonary bypass pump, Altered fibrinolysis","breadcrumb":{"@id":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/#primaryimage","url":"","contentUrl":""},{"@type":"BreadcrumbList","@id":"https:\/\/johnsonfrancis.org\/professional\/specific-risk-for-bleeding-with-cabg\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/johnsonfrancis.org\/professional\/"},{"@type":"ListItem","position":2,"name":"Specific risk for bleeding with CABG"}]},{"@type":"WebSite","@id":"https:\/\/johnsonfrancis.org\/professional\/#website","url":"https:\/\/johnsonfrancis.org\/professional\/","name":"All About Cardiovascular System and Disorders","description":"","publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/johnsonfrancis.org\/professional\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":["Person","Organization"],"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec","name":"Johnson Francis","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","caption":"Johnson Francis"},"logo":{"@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g"},"description":"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal","url":"https:\/\/johnsonfrancis.org\/professional\/author\/jf\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/11499","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/comments?post=11499"}],"version-history":[{"count":0,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/11499\/revisions"}],"wp:attachment":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/media?parent=11499"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/categories?post=11499"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/tags?post=11499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}