{"id":11669,"date":"2014-04-06T06:34:30","date_gmt":"2014-04-06T06:34:30","guid":{"rendered":"http:\/\/cardiophile.org\/?p=11669"},"modified":"2023-03-29T13:27:59","modified_gmt":"2023-03-29T07:57:59","slug":"familial-mitral-valve-prolapse-mvp-autosomal-dominant-inheritance","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/familial-mitral-valve-prolapse-mvp-autosomal-dominant-inheritance\/","title":{"rendered":"Familial Mitral Valve Prolapse (MVP)"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/2HaQDA1ggPw\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen=\"\"><\/iframe><\/p>\n<h2><span style=\"color: #008000;\">Familial mitral valve prolapse (MVP)<\/span><\/h2>\n<p>Inheritance pattern of mitral valve prolapse has been thought to be in an autosomal dominant pattern. Devereux et al [1] studied 45 probands and 179 first degree relatives to check the inheritance pattern if any. 54 of the 179 first degree relatives (30%) had echocardiographic evidence of mitral valve prolapse. In 29 families, at least one first degree relative had mitral valve prolapse. The incidence was higher in females with 37 of the 90 females (41%) having MVP while only 17 of the 89 men (19%; P&lt;0.005) had it.<\/p>\n<p>A P637Q mutation in the filamin A (FLNA) gene has been identified in X-linked myxomatous valvular dystrophy [2]. In the X-linked variety, penetrance in men was complete while it was incomplete in women, as expected.<\/p>\n<p><strong><span style=\"color: #0000ff;\">References<\/span><\/strong><\/p>\n<ol>\n<li>R B Devereux, W T Brown, R Kramer-Fox, I Sachs.&nbsp;<a style=\"font-size: inherit;\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7149490\">Inheritance of mitral valve prolapse: effect of age and sex on gene expression.<\/a> Ann Intern Med. 1982;97:826-32.<\/li>\n<li>Florence Kyndt, Jean-Pierre Gueffet, Vincent Probst, Philippe Jaafar, Antoine Legendre, Fran\u00e7oise Le Bouffant, Claire Toquet, Estelle Roy, Lesley McGregor, Sally Ann Lynch, Ruth Newbury-Ecob, Vinh Tran, Ian Young, Jean-Noel Trochu, Herv\u00e9 Le Marec, Jean-Jacques Schott.&nbsp;<a style=\"font-size: inherit;\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17190868\">Mutations in the Gene Encoding Filamin A as a Cause for Familial Cardiac Valvular Dystrophy.<\/a>&nbsp;Circulation. 2007; 115:40-49.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Familial mitral valve prolapse (MVP) Inheritance pattern of mitral valve prolapse has been thought to be in an autosomal dominant pattern. Devereux et al [1] studied 45 probands and 179 first degree relatives to check the inheritance pattern if any. 54 of the 179 first degree relatives (30%) had echocardiographic evidence of mitral valve prolapse. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":58995,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[420,421,422,1449,1450,1451,1483,1513,2419,2512,4273],"class_list":["post-11669","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","tag-autosominal-dominant-inheritance","tag-autosominal-dominant-pattern","tag-autosominal-dominant-transmission","tag-familial-cardiac-valvular-dystrophy","tag-familial-mitral-valve-prolapse","tag-familial-mvp","tag-filamin-a","tag-flna","tag-mitral-valve-prolapse","tag-mvp","tag-x-linked-myxomatous-valvular-dystrophy"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Familial Mitral Valve Prolapse (MVP) - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"description\" content=\"Inheritance pattern of familial mitral valve prolapse has been thought to be in an autosominal dominant pattern and rarely X-linked.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/familial-mitral-valve-prolapse-mvp-autosomal-dominant-inheritance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Familial Mitral Valve Prolapse (MVP) - 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