{"id":12,"date":"2008-11-16T11:07:13","date_gmt":"2008-11-16T11:07:13","guid":{"rendered":"http:\/\/cardiophile.info\/?p=12"},"modified":"2008-11-16T11:07:13","modified_gmt":"2008-11-16T11:07:13","slug":"ace-angiotensin-converting-enzyme-gene-and-cad","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/ace-angiotensin-converting-enzyme-gene-and-cad\/","title":{"rendered":"ACE gene and CAD"},"content":{"rendered":"

ACE gene and CAD<\/span><\/h2>\n

ACE gene and CAD: Patients with a homozygous deletional form of the ACE gene (dd) have increased circulating ACE level and hence are more likely to develop myocardial infarction [1].<\/p>\n

Myocardial levels of ACE (angiotensin converting enzyme) are higher in patients with the dd gene [2].<\/p>\n

Quinapril prevents restenosis after stenting in patients with ACE D allele [3]. Higher minimal luminal diameter (MLD) lower diameter stenosis (22.9 vs 37.1 %, p < 0.05) was noted in patients with the D allele although there was no difference in those with the II genotype.<\/p>\n

Intravascular ultrasound (IVUS) documented the prevention of loss of MLD in patients with the D allele compared to those with the II genotype. It was concluded that attenuation of lumen loss of the implantation of a coronary stent was better in those with D allele of the ACE gene [3].<\/p>\n

References<\/strong><\/span><\/p>\n

    \n
  1. Fran\u00e7ois Cambien, Odette Poirier, Laure Lecerf, Alun Evans, Jean-Pierre Cambou, Dominique Arveiler, Gerald Luc, Jean-Marie Bard, Lucienne Bara, Sylvain Ricard, Laurence Tiret, Philippe Amouyel, Fran\u00e7ois Alhenc-Gelas & Florent Soubrier. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction<\/a>. Nature. 1992 Oct 15;359(6396):641-4.<\/li>\n
  2. A H Danser, M A Schalekamp, W A Bax, A M van den Brink, P R Saxena, G A Riegger, H Schunkert. Angiotensin-converting enzyme in the human heart. Effect of the deletion\/insertion polymorphism<\/a>. Circulation. 1995 Sep 15;92(6):1387-8.<\/li>\n
  3. Kenji Okumura, Takahito Sone, Junichiro Kondo, Hideyuki Tsuboi, Hiroaki Mukawa, Michitaka Tsuzuki, Hajime Imai, Hiroki Kamiya, Yukio Mabuchi, Hideo Matsui, Tetsuo Hayakawa. Quinapril prevents restenosis after coronary stenting in patients with angiotensin-converting enzyme D allele<\/a>. Circ J. 2002 Apr;66(4):311-6.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

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