{"id":14294,"date":"2014-08-27T16:34:25","date_gmt":"2014-08-27T16:34:25","guid":{"rendered":"http:\/\/cardiophile.org\/?p=14294"},"modified":"2023-01-20T06:59:44","modified_gmt":"2023-01-20T01:29:44","slug":"nebivolol-and-beta-3-mediated-cardioprotection","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/nebivolol-and-beta-3-mediated-cardioprotection\/","title":{"rendered":"Nebivolol and beta 3 mediated cardioprotection"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/pC5iZ7GvjV4\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen=\"\"><\/iframe><\/p>\n<h2><span style=\"color: #008000;\">Nebivolol and beta 3 mediated cardioprotection<\/span><\/h2>\n<p>Nebivolol and beta 3 mediated cardioprotection: Beta 3 adrenoceptor stimulation has been shown to have cardioprotection mediated through nitric oxide synthase which produces nitric oxide. Nebivolol has higher beta 1 selectivity than bisoprolol, carvedilol and bucindolol. Nebivolol is a vasodilatory beta blocker useful in treatment of heart failure in addition to routine uses for beta blockers. The vasodilatory property of nebivolol is probably mediated through stimulation of beta 3 receptors which in turn leads to endothelial nitric oxide synthase (eNOS) activation resulting in the release of nitric oxide. This improves endothelial function and produces peripheral vasodilatation.<\/p>\n<p>Nebivolol has effect on neuronal nitric oxide synthase (nNOS) as well. The cardioprotective effect of nebivolol is abolished in experimental animals by administration of beta 3 antagonists. Nebivolol can reduce ventricular remodeling and preserve left ventricular function by beta 3 adrenoceptor mediated pathways. Nebivolol has been shown to reduce myocardial injury and mortality in mice.<sup>1<\/sup> It also reduces the amount myocardial scar and severe fibrosis.<\/p>\n<p><span style=\"color: #0000ff;\"><strong>References<\/strong><\/span><\/p>\n<ol>\n<li>Zhang Z, Ding L, Jin Z, Gao G, Li H, Zhang L, Zhang L, Lu X, Hu L, Lu B, Yu X, Hu T. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24849208\">Nebivolol Protects against Myocardial Infarction Injury via Stimulation of Beta 3-Adrenergic Receptors and Nitric Oxide Signaling<\/a>. PLoS One. 2014; 9: e98179.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Nebivolol and beta 3 mediated cardioprotection: Probable mechanism: eNOS activation resulting in the release of nitric oxide and vasodilation.<\/p>\n","protected":false},"author":1,"featured_media":33574,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-14294","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nebivolol and beta 3 mediated cardioprotection - NOS mediated<\/title>\n<meta name=\"description\" content=\"Nebivolol and beta 3 mediated cardioprotection: Probable mechanism: eNOS activation resulting in the release of nitric oxide and vasodilation.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/nebivolol-and-beta-3-mediated-cardioprotection\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nebivolol and beta 3 mediated cardioprotection - 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