{"id":185,"date":"2008-10-02T07:05:57","date_gmt":"2008-10-02T07:05:57","guid":{"rendered":"http:\/\/cardiophile.org\/?p=185"},"modified":"2008-10-02T07:05:57","modified_gmt":"2008-10-02T07:05:57","slug":"bivalirudin-hirulog","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/bivalirudin-hirulog\/","title":{"rendered":"Bivalirudin"},"content":{"rendered":"

Bivalirudin <\/span><\/h2>\n

Bivalirudin is a synthetic 20 amino acid polypeptide. It interacts bivalently with both active catalytic site and exosite 1 of thrombin. Bivalirudin inactivates both free and fibrin bound thrombin. It has a short half life of 25 minutes, which confers a potential safety advantage. Half life may be increased in renal failure. Bivalirudin is useful in HITS (Heparin Induced Thrombocytopenia Syndrome) in which anticoagulation is needed in view thrombotic milieu, especially in HITTS or Heparin Induced Thrombotic Thrombocytopenia Syndrome).
\nISAR-REACT 3 [1], REPLACE-2 [2], ACUITY [3] and HORIZONS-AMI Trials have shown the efficacy of Bivalirudin.<\/p>\n

References<\/span><\/strong><\/p>\n

    \n
  1. Kastrati A, Neumann FJ, Mehilli J, Byrne RA, Iijima R, B\u00fcttner HJ, Khattab AA, Schulz S, Blankenship JC, Pache J, Minners J, Seyfarth M, Graf I, Skelding KA, Dirschinger J, Richardt G, Berger PB, Sch\u00f6mig A; ISAR-REACT 3 Trial Investigators.\u00a0Bivalirudin versus unfractionated heparin during percutaneous coronary intervention<\/a>.\u00a0N Engl J Med. 2008 Aug 14;359(7):688-96.<\/li>\n
  2. Lincoff AM, Bittl JA, Harrington RA, Feit F, Kleiman NS, Jackman JD, Sarembock IJ, Cohen DJ, Spriggs D, Ebrahimi R, Keren G, Carr J, Cohen EA, Betriu A, Desmet W, Kereiakes DJ, Rutsch W, Wilcox RG, de Feyter PJ, Vahanian A, Topol EJ; REPLACE-2 Investigators. Bivalirudin and provisional glycoprotein IIb\/IIIa blockade compared with heparin and planned glycoprotein IIb\/IIIa blockade during percutaneous coronary intervention: REPLACE-2 randomized trial. JAMA. 2003 Feb 19;289(7):853-63.<\/li>\n
  3. Stone GW, McLaurin BT, Cox DA, Bertrand ME, Lincoff AM, Moses JW, White HD, Pocock SJ, Ware JH, Feit F, Colombo A, Aylward PE, Cequier AR, Darius H, Desmet W, Ebrahimi R, Hamon M, Rasmussen LH, Rupprecht HJ, Hoekstra J, Mehran R, Ohman EM; ACUITY Investigators.\u00a0Bivalirudin for patients with acute coronary syndromes.\u00a0N Engl J Med. 2006 Nov 23;355(21):2203-16.<\/li>\n
  4. Stone GW, Witzenbichler B, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, Kornowski R, Hartmann F, Gersh BJ, Pocock SJ, Dangas G, Wong SC, Kirtane AJ, Parise H, Mehran R; HORIZONS-AMI Trial Investigators.\u00a0Bivalirudin during primary PCI in acute myocardial infarction.\u00a0N Engl J Med. 2008 May 22;358(21):2218-30.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Bivalirudin is a synthetic 20 amino acid polypeptide. It interacts bivalently with both active catalytic site and exosite 1 of thrombin.\u00a0Bivalirudin inactivates both free and fibrin bound thrombin.<\/p>\n","protected":false},"author":1,"featured_media":38274,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-185","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"\nBivalirudin - Useful in HITS if anticoagulation is needed<\/title>\n<meta name=\"description\" content=\"Bivalirudin is a synthetic 20 amino acid polypeptide. 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