{"id":19201,"date":"2015-06-05T05:49:39","date_gmt":"2015-06-05T00:19:39","guid":{"rendered":"https:\/\/cardiophile.org\/?p=19201"},"modified":"2022-12-28T05:49:26","modified_gmt":"2022-12-28T00:19:26","slug":"anthracycline-cardiotoxicity-clinical-types","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/","title":{"rendered":"Anthracycline Cardiotoxicity &#8211; Clinical Types"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/inqtGTBYwfI\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\"><\/iframe><\/p>\n<h2><span style=\"color: #008000;\">Anthracycline cardiotoxicity &#8211; clinical types<\/span><\/h2>\n<p>Anthracyclines are very effective in the chemotherapy of cancer. But their Achilles heel is <a href=\"https:\/\/johnsonfrancis.org\/professional\/pegylated-liposomal-doxorubicin-lower-cardiotoxicity-2\/\">cardiotoxicity<\/a>. Three clinical types of anthracycline cardiotoxicity have been described [1]:<\/p>\n<ol>\n<li>Acute &#8211; usually occurring within two weeks of initiation of treatment, with the first dose or first course of chemotherapy.<\/li>\n<li>Early onset chronic &#8211; usually occurring within a year. This is the most frequent type and presents with features suggesting dilated cardiomyopathy.<\/li>\n<li>Late onset chronic &#8211; occurs years or even decades later.<\/li>\n<\/ol>\n<p>Acute cardiotoxicity though rare, is potentially lethal and may include pericarditis and arrhythmias [2] additional manifestations over and above left ventricular dysfunction. Twenty four hour Holter monitoring showed that only 3% had arrhythmia within the first hour after infusion and 24% in subsequent 23 hours. But no acute or long term adverse consequences related to the arrhythmia were noted in that study. Mechanism of acute cardiotoxicity may be inflammatory and different from that of chronic toxicities.<\/p>\n<p>Cardiotoxicity has been classified into type I and II. Type I is caused by death of cardiomyocyte by necrosis or apoptosis and not reversible. Long term toxicity belongs to this type. Type II is due to cardiomyocyte dysfunction and may be reversible.<\/p>\n<p><span style=\"color: #0000ff;\"><strong>References<\/strong><\/span><\/p>\n<ol>\n<li>Volkova M, Russell R 3rd. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3322439\/\">Anthracycline cardiotoxicity: prevalence, pathogenesis and treatment<\/a>. Curr Cardiol Rev. 2011 Nov;7(4):214-20.<\/li>\n<li>Steinberg JS, Cohen AJ, Wasserman AG, Cohen P, Ross AM. Acute arrhythmogenicity of doxorubicin administration. Cancer. 1987 Sep 15;60(6):1213-8.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Clinical types of anthracycline cardiotoxicity are acute, early onset chronic and late onset chronic varieties. The last one can occur even decades later.<\/p>\n","protected":false},"author":1,"featured_media":33208,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-19201","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Anthracycline cardiotoxicity - Acute, Early onset chronic, Late onset chronic<\/title>\n<meta name=\"description\" content=\"Anthracycline cardiotoxicity - clinical types: Acute - within 2 weeks, Early onset chronic - within a year, Late onset chronic - years or decades later.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Anthracycline cardiotoxicity - Acute, Early onset chronic, Late onset chronic\" \/>\n<meta property=\"og:description\" content=\"Anthracycline cardiotoxicity - clinical types: Acute - within 2 weeks, Early onset chronic - within a year, Late onset chronic - years or decades later.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2015-06-05T00:19:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-12-28T00:19:26+00:00\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"Anthracycline Cardiotoxicity &#8211; Clinical Types\",\"datePublished\":\"2015-06-05T00:19:39+00:00\",\"dateModified\":\"2022-12-28T00:19:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/\"},\"wordCount\":235,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"articleSection\":[\"General Cardiology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/\",\"name\":\"Anthracycline cardiotoxicity - Acute, Early onset chronic, Late onset chronic\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"datePublished\":\"2015-06-05T00:19:39+00:00\",\"dateModified\":\"2022-12-28T00:19:26+00:00\",\"description\":\"Anthracycline cardiotoxicity - clinical types: Acute - within 2 weeks, Early onset chronic - within a year, Late onset chronic - years or decades later.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/#primaryimage\",\"url\":\"\",\"contentUrl\":\"\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/anthracycline-cardiotoxicity-clinical-types\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Anthracycline Cardiotoxicity &#8211; Clinical Types\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\",\"name\":\"All About Cardiovascular System and Disorders\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\",\"name\":\"Johnson Francis\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"caption\":\"Johnson Francis\"},\"logo\":{\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\"},\"description\":\"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/author\\\/jf\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Anthracycline cardiotoxicity - Acute, Early onset chronic, Late onset chronic","description":"Anthracycline cardiotoxicity - clinical types: Acute - within 2 weeks, Early onset chronic - within a year, Late onset chronic - years or decades later.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/","og_locale":"en_US","og_type":"article","og_title":"Anthracycline cardiotoxicity - Acute, Early onset chronic, Late onset chronic","og_description":"Anthracycline cardiotoxicity - clinical types: Acute - within 2 weeks, Early onset chronic - within a year, Late onset chronic - years or decades later.","og_url":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/","og_site_name":"All About Cardiovascular System and Disorders","article_published_time":"2015-06-05T00:19:39+00:00","article_modified_time":"2022-12-28T00:19:26+00:00","author":"Johnson Francis","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Johnson Francis","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/#article","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/"},"author":{"name":"Johnson Francis","@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"headline":"Anthracycline Cardiotoxicity &#8211; Clinical Types","datePublished":"2015-06-05T00:19:39+00:00","dateModified":"2022-12-28T00:19:26+00:00","mainEntityOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/"},"wordCount":235,"publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/#primaryimage"},"thumbnailUrl":"","articleSection":["General Cardiology"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/","url":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/","name":"Anthracycline cardiotoxicity - Acute, Early onset chronic, Late onset chronic","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#website"},"primaryImageOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/#primaryimage"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/#primaryimage"},"thumbnailUrl":"","datePublished":"2015-06-05T00:19:39+00:00","dateModified":"2022-12-28T00:19:26+00:00","description":"Anthracycline cardiotoxicity - clinical types: Acute - within 2 weeks, Early onset chronic - within a year, Late onset chronic - years or decades later.","breadcrumb":{"@id":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/#primaryimage","url":"","contentUrl":""},{"@type":"BreadcrumbList","@id":"https:\/\/johnsonfrancis.org\/professional\/anthracycline-cardiotoxicity-clinical-types\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/johnsonfrancis.org\/professional\/"},{"@type":"ListItem","position":2,"name":"Anthracycline Cardiotoxicity &#8211; Clinical Types"}]},{"@type":"WebSite","@id":"https:\/\/johnsonfrancis.org\/professional\/#website","url":"https:\/\/johnsonfrancis.org\/professional\/","name":"All About Cardiovascular System and Disorders","description":"","publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/johnsonfrancis.org\/professional\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":["Person","Organization"],"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec","name":"Johnson Francis","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","caption":"Johnson Francis"},"logo":{"@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g"},"description":"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal","url":"https:\/\/johnsonfrancis.org\/professional\/author\/jf\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/19201","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/comments?post=19201"}],"version-history":[{"count":3,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/19201\/revisions"}],"predecessor-version":[{"id":57766,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/19201\/revisions\/57766"}],"wp:attachment":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/media?parent=19201"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/categories?post=19201"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/tags?post=19201"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}