{"id":22227,"date":"2017-10-18T07:03:51","date_gmt":"2017-10-18T01:33:51","guid":{"rendered":"https:\/\/cardiophile.org\/?p=22227"},"modified":"2021-12-20T22:44:24","modified_gmt":"2021-12-20T17:14:24","slug":"proprotein-convertase-subtilisinkexin-type-9-pcsk9-cardiology-mcq-answer","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/proprotein-convertase-subtilisinkexin-type-9-pcsk9-cardiology-mcq-answer\/","title":{"rendered":"Proprotein convertase subtilisin\/kexin type 9 (PCSK9) – Cardiology MCQ – Answer"},"content":{"rendered":"

\"\"
\nCorrect answer:\u00a0<\/strong><\/span><\/p>\n

    \n
  1. Secreted into plasma by kidney<\/li>\n<\/ol>\n

    Proprotein convertase subtilisin\/kexin type 9 (PCSK9) is secreted into plasma by liver<\/span> and not the kidney. Binding of PCSK9 to LDL receptors on hepatocytes enhances degradation of the LDL receptors by endosomes. This in turn leads to reduced LDL clearance. Inhibition of PCSK9 with monoclonal antibodies reduce atherosclerosis and cardiovascular events. Read more on PCSK9 inhibitors…<\/a>
    \nReference<\/strong><\/p>\n

      \n
    1. Bayes-Genis A et al. The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure.\u00a0BIOSTAT-CHF Subanalysis. J Am Coll Cardiol. 2017; 70:2128-36.<\/li>\n<\/ol>\n

      Back to question<\/strong><\/a>
      \n <\/p>\n","protected":false},"excerpt":{"rendered":"

      Correct answer:\u00a0 Secreted into plasma by kidney Proprotein convertase subtilisin\/kexin type 9 (PCSK9) is secreted into plasma by liver and not the kidney. Binding of PCSK9 to LDL receptors on hepatocytes enhances degradation of the LDL receptors by endosomes. This in turn leads to reduced LDL clearance. Inhibition of PCSK9 with monoclonal antibodies reduce atherosclerosis […]<\/p>\n","protected":false},"author":1,"featured_media":17497,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[3,5],"tags":[],"class_list":["post-22227","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiology-mcq","category-dm-dnb-cardiology-entrance"],"yoast_head":"\nProprotein convertase subtilisin\/kexin type 9 (PCSK9) - Cardiology MCQ - Answer - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/proprotein-convertase-subtilisinkexin-type-9-pcsk9-cardiology-mcq-answer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Proprotein convertase subtilisin\/kexin type 9 (PCSK9) - Cardiology MCQ - Answer - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"Correct answer:\u00a0 Secreted into plasma by kidney Proprotein convertase subtilisin\/kexin type 9 (PCSK9) is secreted into plasma by liver and not the kidney. Binding of PCSK9 to LDL receptors on hepatocytes enhances degradation of the LDL receptors by endosomes. This in turn leads to reduced LDL clearance. Inhibition of PCSK9 with monoclonal antibodies reduce atherosclerosis […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/proprotein-convertase-subtilisinkexin-type-9-pcsk9-cardiology-mcq-answer\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2017-10-18T01:33:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-12-20T17:14:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/johnsonfrancis.org\/professional\/wp-content\/uploads\/2014\/10\/cardiology-mcq1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"701\" \/>\n\t<meta property=\"og:image:height\" content=\"517\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/proprotein-convertase-subtilisinkexin-type-9-pcsk9-cardiology-mcq-answer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/proprotein-convertase-subtilisinkexin-type-9-pcsk9-cardiology-mcq-answer\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"Proprotein convertase subtilisin\\\/kexin type 9 (PCSK9) – Cardiology MCQ – Answer\",\"datePublished\":\"2017-10-18T01:33:51+00:00\",\"dateModified\":\"2021-12-20T17:14:24+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/proprotein-convertase-subtilisinkexin-type-9-pcsk9-cardiology-mcq-answer\\\/\"},\"wordCount\":100,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/proprotein-convertase-subtilisinkexin-type-9-pcsk9-cardiology-mcq-answer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/wp-content\\\/uploads\\\/2014\\\/10\\\/cardiology-mcq1.png\",\"articleSection\":[\"Cardiology MCQ\",\"DM \\\/ DNB Cardiology Entrance\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/proprotein-convertase-subtilisinkexin-type-9-pcsk9-cardiology-mcq-answer\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/proprotein-convertase-subtilisinkexin-type-9-pcsk9-cardiology-mcq-answer\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/proprotein-convertase-subtilisinkexin-type-9-pcsk9-cardiology-mcq-answer\\\/\",\"name\":\"Proprotein convertase subtilisin\\\/kexin type 9 (PCSK9) - 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