{"id":22537,"date":"2017-11-15T14:44:01","date_gmt":"2017-11-15T09:14:01","guid":{"rendered":"https:\/\/cardiophile.org\/?p=22537"},"modified":"2022-11-29T04:55:01","modified_gmt":"2022-11-28T23:25:01","slug":"supplemental-oxygen-in-stemi-without-hypoxia-avoid","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/supplemental-oxygen-in-stemi-without-hypoxia-avoid\/","title":{"rendered":"Supplemental oxygen in STEMI  without hypoxia &#8211; AVOID"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/sfrGVbEyIyY\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\"><\/iframe><\/p>\n<h2><span style=\"color: #008000;\">Supplemental oxygen in STEMI without hypoxia &#8211; AVOID<\/span><\/h2>\n<p>It was routine practice to give supplemental oxygen to those presenting to emergency department with ST elevation myocardial infarction. Two trials &#8211; AVOID [1] and DETO2X-AMI [2] have critically appraised the value of supplemental oxygen in STEMI.<\/p>\n<p>AVOID study showed that in STEMI patients without hypoxia, supplemental oxygen can increase early myocardial injury which was demonstrated by a higher value of creatine phosphokinase. Larger myocardial infarct size as assessed by cardiac magnetic resonance imaging was noted at six months. Higher rate of recurrent myocardial infarction and increased frequency of cardiac arrhythmia were observed.<\/p>\n<p>DETO2X-AMI study randomly assigned 6629 patients with STEMI and oxygen saturation of 90% or more to either supplemental oxygen 6 liters per minute for 6-12 hours through an open face mask or ambient air. There was no reduction of one year mortality with oxygen administration in those without hypoxia.<\/p>\n<p>The recommendation was that supplemental oxygen is indicated only if the oxygen saturation is less than 90% or partial pressure of oxygen is less than 60 mm Hg. Hyperoxia may be harmful in patients with uncomplicated STEMI, presumably due to increased myocardial injury.<\/p>\n<p><span style=\"color: #0000ff;\"><strong>References<\/strong><\/span><\/p>\n<ol>\n<li>Stub D et al; AVOID Investigators. Air Versus Oxygen in ST-Segment-Elevation Myocardial Infarction.&nbsp;Circulation. 2015 Jun 16;131(24):2143-50.<\/li>\n<li>Hofmann R et al; DETO2X\u2013SWEDEHEART Investigators. Oxygen Therapy in Suspected Acute Myocardial Infarction.&nbsp;N Engl J Med. 2017 Sep 28;377(13):1240-1249.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>The recommendation is that supplemental oxygen is indicated only if the oxygen saturation (SaO2 or SPO2) is less than 90% or partial pressure of oxygen (PaO2) is less than 60 mm Hg. Hyperoxia may be harmful in patients with uncomplicated STEMI, presumably due to increased myocardial injury.<\/p>\n","protected":false},"author":1,"featured_media":22539,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-22537","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Supplemental oxygen in STEMI without hypoxia - AVOID - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"description\" content=\"The recommendation is that supplemental oxygen is indicated only if the oxygen saturation (SaO2 or SPO2) is less than 90% or partial pressure of oxygen (PaO2) is less than 60 mm Hg. Hyperoxia may be harmful in patients with uncomplicated STEMI, presumably due to increased myocardial injury.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/supplemental-oxygen-in-stemi-without-hypoxia-avoid\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Supplemental oxygen in STEMI without hypoxia - AVOID - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"The recommendation is that supplemental oxygen is indicated only if the oxygen saturation (SaO2 or SPO2) is less than 90% or partial pressure of oxygen (PaO2) is less than 60 mm Hg. 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