{"id":24580,"date":"2018-06-06T05:40:21","date_gmt":"2018-06-06T00:10:21","guid":{"rendered":"https:\/\/cardiophile.org\/?p=24580"},"modified":"2018-06-06T05:40:21","modified_gmt":"2018-06-06T00:10:21","slug":"switching-from-acei-to-arni-cardiology-mcq-answer","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/switching-from-acei-to-arni-cardiology-mcq-answer\/","title":{"rendered":"Switching from ACEI to ARNI &#8211; Cardiology MCQ &#8211; Answer"},"content":{"rendered":"<h2><strong><span style=\"color: #008000;\">While switching over from an ACE inhibitor to ARNI, ARNI can be started &#8212; hours after ACEI:<\/span><\/strong><\/h2>\n<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/b9x0oYWSyV8\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\"><\/iframe><br \/>\n<span style=\"color: #0000ff;\"><b>Correct answer:&nbsp;<\/b><strong>c) 36 hours<\/strong><\/span><br \/>\nCombination of ACEI (angiotensin converting enzyme inhibitor) and neprilysin inhibitor can lead to higher rates of angioedema as both can lead to accumulation of bradykinin [1]. Bradykinin is inactivated by angiotensin converting enzyme and neprilysin.<br \/>\nAnother drug omapatrilat which is an inhibitor of neprilysin, aminopeptidase P and ACE was tried for hypertension and heart failure. All the three enzymes are involved in inactivation of bradykinin [2]. The development of the drug was discontinued because of higher incidence of angioedema.<br \/>\n<a href=\"\/professional\/switching-from-acei-to-arni-cardiology-mcq\/\"><strong>Back to&nbsp;<\/strong><b>question<\/b><\/a><br \/>\n<span style=\"color: #0000ff;\"><strong>Reference<\/strong><\/span><\/p>\n<ol>\n<li>Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Colvin MM, Drazner MH, Filippatos GS, Fonarow GC, Givertz MM, Hollenberg SM, Lindenfeld J, Masoudi FA, McBride PE, Peterson PN, Stevenson LW, Westlake C.&nbsp;2017 ACC\/AHA\/HFSA Focused Update of the 2013 ACCF\/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America.&nbsp;Circulation. 2017 Aug 8;136(6):e137-e161.<\/li>\n<li>McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR; PARADIGM-HF Investigators and Committees.&nbsp;Angiotensin-neprilysin inhibition versus enalapril in heart failure.&nbsp;N Engl J Med. 2014 Sep 11;371(11):993-1004.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>While switching over from an ACE inhibitor to ARNI, ARNI can be started &#8212; hours after ACEI: Correct answer:&nbsp;c) 36 hours Combination of ACEI (angiotensin converting enzyme inhibitor) and neprilysin inhibitor can lead to higher rates of angioedema as both can lead to accumulation of bradykinin [1]. Bradykinin is inactivated by angiotensin converting enzyme and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[3,5],"tags":[],"class_list":["post-24580","post","type-post","status-publish","format-standard","hentry","category-cardiology-mcq","category-dm-dnb-cardiology-entrance"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Switching from ACEI to ARNI - Cardiology MCQ - Answer - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/switching-from-acei-to-arni-cardiology-mcq-answer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Switching from ACEI to ARNI - Cardiology MCQ - Answer - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"While switching over from an ACE inhibitor to ARNI, ARNI can be started &#8212; hours after ACEI: Correct answer:&nbsp;c) 36 hours Combination of ACEI (angiotensin converting enzyme inhibitor) and neprilysin inhibitor can lead to higher rates of angioedema as both can lead to accumulation of bradykinin [1]. 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