{"id":40711,"date":"2020-10-10T12:46:26","date_gmt":"2020-10-10T07:16:26","guid":{"rendered":"https:\/\/johnsonfrancis.org\/professional\/?p=40711"},"modified":"2020-10-10T12:46:26","modified_gmt":"2020-10-10T07:16:26","slug":"ventricular-septal-defect","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/ventricular-septal-defect\/","title":{"rendered":"Ventricular septal defect"},"content":{"rendered":"<h2><span style=\"color: #008000;\">Ventricular septal defect<\/span><\/h2>\n<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/DYN4ZNpvcBM\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\"><\/iframe><\/p>\n<p>Ventricular septal defects (VSD) can be divided into perimembranous, muscular, inlet and outlet VSDs, depending on the location. Of these perimembranous VSDs are the commonest. VSDs can decrease in size and undergo spontaneous closure. Spontaneous closure is most likely with small muscular and perimembranous VSD, while inlet and outlet VSDs are least likely to close.<\/p>\n<p><strong>Perimembranous ventricular septal defect<\/strong><\/p>\n<figure id=\"attachment_40712\" aria-describedby=\"caption-attachment-40712\" style=\"width: 1200px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-40712\" src=\"https:\/\/johnsonfrancis.org\/professional\/wp-content\/uploads\/2020\/10\/Perimembraneous-aneurysm-with-VSD-Jet.jpg\" alt=\"Perimembranous VSD with perimembranous aneurysm\" width=\"1200\" height=\"685\"><figcaption id=\"caption-attachment-40712\" class=\"wp-caption-text\">Perimembranous VSD with perimembranous aneurysm<\/figcaption><\/figure>\n<p><em>Echocardiogram in ventricular septal defect: Parasternal long axis view shows the subaortic perimembranous ventricular septal aneurysm (marked by arrows). The color mosaic jet from the left ventricular outflow tract into the right ventricle is seen in the right panel (VSD Jet). There is a perimembranous aneurysm meaning the VSD is on the closure path.<\/em><\/p>\n<p>Perimembranous VSD is located in the left ventricular outflow tract and if large can involve the muscular septum in addition to the perimembranous septum. The mechanisms of spontaneous closure include:<\/p>\n<p>1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Closure by aneurysm formation<\/p>\n<p>2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Closure by prolapse of the aortic valve<\/p>\n<p>3.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Closure by attachment of septal tricuspid leaflet<\/p>\n<p>4.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Closure by ingrowth of tissue<\/p>\n<p>When prolapse of aortic valve occurs, there is associated aortic regurgitation which can progress over the years. Similarly, when the closure is by attachment of the septal tricuspid leaflet, there can be tricuspid regurgitation. If there is a fenestration of the tricuspid leaflet, there is a left ventricle to right atrium shunt (LV-RA shunt). The other cause of LV-RA shunt is an <em>atrioventricular septal defect<\/em> or <em>Gerbode VSD<\/em>.<\/p>\n<p><strong>Muscular ventricular septal defect<\/strong><\/p>\n<p>Muscular VSD can be anywhere along the muscular septum and can be multiple. Multiple muscular VSDs are known as <em>Swiss cheese VSD<\/em> &nbsp;and are difficult to close surgically. Small apical muscular VSD has a soft apical systolic murmur of shorter duration unlike the loud pan systolic murmur in the parasternal region of the other VSDs. This is because the defect is occluded by ventricular muscle contraction in the latter part of the systole.<\/p>\n<p><strong>Inlet ventricular septal defect<\/strong><\/p>\n<p>Inlet ventricular septal defect is part of the endocardial cushion defects and can be associated with ostium primum atrial septal defect and atrioventricular valve regurgitation. The ventricular septal defect associated with Down syndrome is usually of this type. If both inlet VSD and ostium primum atrial septal defect are present, then it is called a complete atrioventricular (AV) canal defect. Other name for inlet VSD is canal VSD. A cleft in the mitral valve is the reason for the associated mitral regurgitation. Atrioventricular conduction abnormalities may be associated. When there is a complete AV canal defect, a common atrioventricular valve can be present.<\/p>\n<p><strong>Outlet ventricular septal defect<\/strong><\/p>\n<p>Outlet VSDs are also called <em>subpulmonic VSD<\/em> and <em>doubly committed VSD<\/em> and <em>subarterial VSD<\/em> as they are located in the right ventricular outflow tract in relation to both the great vessels. These VSDs are more common in the far East and more likely to have associated aortic regurgitation. Chance for spontaneous closure is low in these and some advocate surgical closure even for outlet VSD to prevent future development of progressive aortic regurgitation.<\/p>\n<p><strong>Clinical findings in VSD<\/strong><\/p>\n<p>Clinical findings depend on size and location of the defect. A small defect produces a loud murmur (<em>maladie de Roger<\/em>), often associated with a thrill in the parasternal region, while the murmur is soft or even inaudible in a large VSD. This is because the pressure in the two ventricles equalizes in large VSD. The murmur may disappear when severe pulmonary hypertension develops and the left to right shunt ceases and a right to left shunt ensues (<em>Eisenmenger reaction<\/em>). Severe pulmonary hypertension develops when there is a large left to right shunt from early infancy due to pulmonary vasoreactivity. In late stages, obliterative changes may occur in the pulmonary vasculature. When this occurs, it is irreversible even after surgical or device closure of the VSD. When there is pulmonary hypertension, there is a loud pulmonary component of second heart sound (P2) which may be palpable and associated with dullness on percussion in 2nd left intercostal space. Right ventricular hypertrophy in this situation is manifest as left parasternal heave. Cyanosis and clubbing occurs in Eisenmenger syndrome. <em>Eisenmenger complex<\/em> is the specific name for VSD Eisenmenger.<\/p>\n<p>The VSD murmur may be higher up in outlet VSD and towards the apex in small apical muscular VSD. In inlet VSD, murmur of associated mitral regurgitation may be audible, but may be difficult to differentiate from VSD murmur.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ventricular septal defect Ventricular septal defects (VSD) can be divided into perimembranous, muscular, inlet and outlet VSDs, depending on the location. Of these perimembranous VSDs are the commonest. VSDs can decrease in size and undergo spontaneous closure. Spontaneous closure is most likely with small muscular and perimembranous VSD, while inlet and outlet VSDs are least [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":40712,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[10],"tags":[408,1208,1310,1313,1578,1867,2291,2509,2722,2848,3657,3744,3760,3808],"class_list":["post-40711","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hbc","tag-atrioventricular-septal-defect","tag-doubly-committed-vsd","tag-eisenmenger-complex","tag-eisenmenger-reaction","tag-gerbode-vsd","tag-inlet-ventricular-septal-defect","tag-maladie-de-roger","tag-muscular-ventricular-septal-defect","tag-outlet-ventricular-septal-defect","tag-perimembranous-ventricular-septal-defect","tag-spontaneous-closure-of-vsd","tag-subarterial-vsd","tag-subpulmonic-vsd","tag-swiss-cheese-vsd"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ventricular septal defect - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/ventricular-septal-defect\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ventricular septal defect - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"Ventricular septal defect Ventricular septal defects (VSD) can be divided into perimembranous, muscular, inlet and outlet VSDs, depending on the location. Of these perimembranous VSDs are the commonest. VSDs can decrease in size and undergo spontaneous closure. Spontaneous closure is most likely with small muscular and perimembranous VSD, while inlet and outlet VSDs are least [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/ventricular-septal-defect\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-10T07:16:26+00:00\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/ventricular-septal-defect\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/ventricular-septal-defect\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"Ventricular septal defect\",\"datePublished\":\"2020-10-10T07:16:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/ventricular-septal-defect\\\/\"},\"wordCount\":765,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/ventricular-septal-defect\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"keywords\":[\"atrioventricular septal defect\",\"doubly committed VSD\",\"Eisenmenger complex\",\"Eisenmenger reaction\",\"Gerbode VSD\",\"Inlet ventricular septal defect\",\"maladie de Roger\",\"Muscular ventricular septal defect\",\"Outlet ventricular septal defect\",\"perimembranous ventricular septal defect\",\"spontaneous closure of VSD\",\"subarterial VSD\",\"subpulmonic VSD\",\"Swiss cheese VSD\"],\"articleSection\":[\"HBC\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/ventricular-septal-defect\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/ventricular-septal-defect\\\/\",\"name\":\"Ventricular septal defect - 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