{"id":40854,"date":"2020-10-15T14:30:52","date_gmt":"2020-10-15T09:00:52","guid":{"rendered":"https:\/\/johnsonfrancis.org\/professional\/?p=40854"},"modified":"2020-10-15T14:30:52","modified_gmt":"2020-10-15T09:00:52","slug":"sotalol-class-iiia","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/sotalol-class-iiia\/","title":{"rendered":"Sotalol \u2013 class IIIa"},"content":{"rendered":"

Sotalol \u2013 class IIIa<\/span><\/h2>\n

Sotalol is a class IIIa antiarrhythmic agent as per the Modernized Classification of Cardiac Antiarrhythmic Drugs [1]. The class effect is voltage dependent K+ channel blocker. Specifically, it is a HERG channel \u2013mediated rapid K+ current (IKr<\/sub>) blocker. It has additional action on beta 1 and beta 2 receptors. Sotalol increases refractory period and decreases tendency for reentry.<\/p>\n

The drug is useful in ventricular tachycardia without structural heart disease and in those with a remote myocardial infarction. It is also useful in atrial fibrillation with conduction through accessory pathway in WPW syndrome. It is also useful in other supraventricular arrhythmias.<\/p>\n

Sotalol is useful in prevention of ventricular fibrillation and premature ventricular contraction.<\/p>\n

The drug has a half life of 12 hours and a 12th hourly dosage is advised. It can cause QTc prolongation and torsades de pointes [3].<\/p>\n

References<\/span><\/strong><\/p>\n

    \n
  1. Ming Lei, Lin Wu, Derek A Terrar, Christopher L-H Huang. Modernized Classification of Cardiac Antiarrhythmic Drugs. Circulation. 2018 Oct 23;138(17):1879-1896.<\/li>\n
  2. Sana M Al-Khatib, William G Stevenson, Michael J Ackerman, William J Bryant, David J Callans, Anne B Curtis, Barbara J Deal, Timm Dickfeld, Michael E Field, Gregg C Fonarow, Anne M Gillis, Christopher B Granger, Stephen C Hammill, Mark A Hlatky, Jos\u00e9 A Joglar, G Neal Kay, Daniel D Matlock, Robert J Myerburg, Richard L Page. 2017 AHA\/ACC\/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2018 Oct 2;72(14):e91-e220.<\/li>\n
  3. Quinn Wells, Bradley Hardin, Satish R Raj, Dawood Darbar. Sotalol-induced torsades de pointes precipitated during treatment with oseltamivir for H1N1 influenza<\/a>. Heart Rhythm. 2010 Oct;7(10):1454-7.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Sotalol \u2013 class IIIa Sotalol is a class IIIa antiarrhythmic agent as per the Modernized Classification of Cardiac Antiarrhythmic Drugs [1]. The class effect is voltage dependent K+ channel blocker. Specifically, it is a HERG channel \u2013mediated rapid K+ current (IKr) blocker. It has additional action on beta 1 and beta 2 receptors. Sotalol increases refractory period […]<\/p>\n","protected":false},"author":1,"featured_media":40858,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-40854","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ecg-electrophysiology"],"yoast_head":"\nSotalol \u2013 class IIIa - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/sotalol-class-iiia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sotalol \u2013 class IIIa - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"Sotalol \u2013 class IIIa Sotalol is a class IIIa antiarrhythmic agent as per the Modernized Classification of Cardiac Antiarrhythmic Drugs [1]. 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