{"id":40888,"date":"2020-10-20T10:52:56","date_gmt":"2020-10-20T05:22:56","guid":{"rendered":"https:\/\/johnsonfrancis.org\/professional\/?p=40888"},"modified":"2020-10-20T10:52:56","modified_gmt":"2020-10-20T05:22:56","slug":"scd-heft-2005","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/scd-heft-2005\/","title":{"rendered":"SCD-HeFT 2005"},"content":{"rendered":"

SCD-HeFT 2005<\/span><\/h2>\n

The Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) trial was published in\u00a0NEJM\u00a0<\/em>in 2005 [1]. SCD-HeFT randomized 2521 patients into three groups. They were in New York Association (NYHA) class II or III congestive heart failure (CHF) and had left ventricular ejection fraction (LVEF) \u226435%. It was a comparison between amiodarone or an implantable cardioverter-defibrillator (ICD) for congestive heart failure, with placebo control. The patients were divided into three groups:<\/p>\n

    \n
  1. Conventional therapy for CHF plus placebo (847 patients)<\/li>\n
  2. Conventional therapy plus amiodarone (845 patients)<\/li>\n
  3. Conventional therapy plus a conservatively programmed, shock-only, single-lead ICD (829 patients)<\/li>\n<\/ol>\n

    Amiodarone and placebo were given in a double blind pattern. Primary endpoint of the study was all cause mortality. Median follow of period of SCD-HeFT was forty five and a half months. Mortality rate was twenty nine percent in the placebo group and twenty eight percent in the amiodarone group. Those on ICD had a mortality rate of twenty two percent.<\/p>\n

    Compared with placebo, amiodarone had a similar death rate with hazard ratio on 1.06 (P=0.53) which was not statistically significant. Death rate was 23 percent lower in the ICD group with a hazard ratio of 0.77 (P=0.007). Absolute reduction in mortality was 7.2% in the ICD group after five years of follow up.<\/p>\n

    Though amiodarone was not found to be superior to placebo in the SCD-HeFT, this was better than the results of the Cardiac Arrhythmia Suppression Trial (CAST) which was published in NEJM\u00a0<\/em>in 1991 [2], which showed excess deaths with encainide or flecainide, two class Ic antiarrhythmic agents.<\/p>\n

    References<\/strong><\/span><\/p>\n

      \n
    1. Gust H Bardy, Kerry L Lee, Daniel B Mark, Jeanne E Poole, Douglas L Packer, Robin Boineau, Michael Domanski, Charles Troutman, Jill Anderson, George Johnson, Steven E McNulty, Nancy Clapp-Channing, Linda D Davidson-Ray, Elizabeth S Fraulo, Daniel P Fishbein, Richard M Luceri, John H Ip, Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005 Jan 20;352(3):225-37.<\/li>\n
    2. D S Echt, P R Liebson, L B Mitchell, R W Peters, D Obias-Manno, A H Barker, D Arensberg, A Baker, L Friedman, H L Greene, Huther ML, Richardson DW, and the CAST Investigators. Mortality and morbidity in patients receiving encainide, flecainide, or placebo<\/a>. The Cardiac Arrhythmia Suppression Trial. N Engl J Med.1991 Mar 21;324(12):781-8.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

      SCD-HeFT 2005 The Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) trial was published in\u00a0NEJM\u00a0in 2005 [1]. SCD-HeFT randomized 2521 patients into three groups. They were in New York Association (NYHA) class II or III congestive heart failure (CHF) and had left ventricular ejection fraction (LVEF) \u226435%. It was a comparison between amiodarone or an […]<\/p>\n","protected":false},"author":1,"featured_media":40889,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-40888","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ecg-electrophysiology"],"yoast_head":"\nSCD-HeFT 2005 - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/scd-heft-2005\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SCD-HeFT 2005 - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"SCD-HeFT 2005 The Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) trial was published in\u00a0NEJM\u00a0in 2005 [1]. SCD-HeFT randomized 2521 patients into three groups. They were in New York Association (NYHA) class II or III congestive heart failure (CHF) and had left ventricular ejection fraction (LVEF) \u226435%. It was a comparison between amiodarone or an […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/scd-heft-2005\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2020-10-20T05:22:56+00:00\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"SCD-HeFT 2005\",\"datePublished\":\"2020-10-20T05:22:56+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/\"},\"wordCount\":372,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"articleSection\":[\"ECG \\\/ Electrophysiology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/\",\"name\":\"SCD-HeFT 2005 - All About Cardiovascular System and Disorders\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"datePublished\":\"2020-10-20T05:22:56+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/#primaryimage\",\"url\":\"\",\"contentUrl\":\"\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/scd-heft-2005\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"SCD-HeFT 2005\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\",\"name\":\"All About Cardiovascular System and Disorders\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\",\"name\":\"Johnson Francis\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"caption\":\"Johnson Francis\"},\"logo\":{\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\"},\"description\":\"Former Professor of Cardiology, Calicut Govt. 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