{"id":413,"date":"2008-10-21T01:30:26","date_gmt":"2008-10-21T01:30:26","guid":{"rendered":"http:\/\/cardiophile.org\/?p=413"},"modified":"2008-10-21T01:30:26","modified_gmt":"2008-10-21T01:30:26","slug":"coenzyme-q10-and-mortality-in-chronic-heart-failure","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/coenzyme-q10-and-mortality-in-chronic-heart-failure\/","title":{"rendered":"Coenzyme Q10 and mortality in chronic heart failure"},"content":{"rendered":"

Coenzyme Q10 and mortality in chronic heart failure<\/span><\/h2>\n

Coenzyme Q10 and mortality in chronic heart failure: Lower Coenzyme Q10 (CoQ10)<\/sub>) levels have been linked to mortality in chronic heart failure in a study published in the Journal of American College of Cardiology<\/em> [1]. CoQ10<\/sub> is an essential cofactor for mitochondrial electron transport and myocardial energy supply. It participates in adenosine triphosphate (ATP) generation by mitochondrial oxidative phosphorylation.<\/p>\n

An earlier study using myocardial biopsies had shown that class IV patients had lower levels of CoQ10<\/sub> than class I (P<0.01). Those in classes III and IV had a lower levels than in classes I and II (P<0.0001) [2].<\/p>\n

Low total cholesterol has been linked with higher mortality in heart failure. Plasma CoQ10<\/sub> levels are associated with LDL cholesterol levels and this might be a link between the two.<\/p>\n

The study by Sarah L Molyneux, Christopher M Florkowski, Peter M George, Anna P Pilbrow, Christopher M Frampton, Michael Lever and A Mark Richards included 236 patients hospitalised for heart failure and found that CoQ10 <\/sub>is an independent predictor of mortality [1]. The median follow up was 2.69 years and median age at admission was 77 years.\u00a0The authors go on to recommend controlled intervention studies with CoQ10 <\/sub>as low CoQ10 <\/sub>levels might be detrimental to prognosis in chronic heart failure.<\/p>\n

Reference<\/span><\/strong><\/p>\n

    \n
  1. Sarah L Molyneux, Christopher M Florkowski, Peter M George, Anna P Pilbrow, Christopher M Frampton, Michael Lever, A Mark Richards. Coenzyme Q10: an independent predictor of mortality in chronic heart failure<\/a>. J Am Coll Cardiol. 2008 Oct 28;52(18):1435-41.<\/li>\n
  2. K Folkers, S Vadhanavikit, S A Mortensen. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10<\/a>. Proc Natl Acad Sci U S A. 1985 Feb;82(3):901-4.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Lower Coenzyme Q10 levels have been linked to mortality in chronic heart failure.<\/p>\n","protected":false},"author":1,"featured_media":38192,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-413","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"\nCoenzyme Q10 and mortality in chronic heart failure<\/title>\n<meta name=\"description\" content=\"Coenzyme Q10 and mortality in chronic heart failure: Lower Coenzyme Q10 levels have been linked to mortality in chronic heart failure.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/coenzyme-q10-and-mortality-in-chronic-heart-failure\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" 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