{"id":4783,"date":"2010-08-20T15:19:48","date_gmt":"2010-08-20T15:19:48","guid":{"rendered":"http:\/\/cardiophile.org\/?p=4783"},"modified":"2010-08-20T15:19:48","modified_gmt":"2010-08-20T15:19:48","slug":"multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque\/","title":{"rendered":"Multicolour CT and gold nanoparticles for evaluation of plaque"},"content":{"rendered":"<h2><span style=\"color: #008000;\">Multicolour CT and gold nanoparticles for evaluation of plaque<\/span><\/h2>\n<p>Multicolour CT and gold nanoparticles for evaluation of plaque: Multicolor CT is the popular name for spectral computed tomography. In spectral CT system, the incident x-rays are divided into multiple energy bins and is used for multicolour imaging. Gold high density nanoparticle contrast agent (Au-HDL) can be used for characterization of macrophage burden as they are taken up by the macrophages in the atherosclerotic plaques. A study published in <em>Radiology<\/em> by David P Cormode, Ewald Roessl, Axel Thran, Torjus Skajaa, Ronald E Gordon, Jens-Peter Schlomka, Valentin Fuster, Edward A Fisher, Willem J M Mulder, Roland Proksa and Zahi A Fayad \u00a0evaluated the use of gold nanoparticles along with multicolour CT in animal studies of atherosclerotic plaques. Multi colour CT enabled differentiation of gold nanoparticles, iodine based contrast and calcium phosphate. Gold nanoparticles were located primarily in the macrophages in the aortic sections. This combined imaging enabled characterization of stenosis by the plaques, calcification and the macrophage burden. Macrophage rich plaques are considered as vulnerable plaques prone for rupture and producing vascular events like acute coronary syndrome.<\/p>\n<p><span style=\"color: #0000ff;\"><strong>Reference<\/strong><\/span><\/p>\n<ol>\n<li>David P Cormode, Ewald Roessl, Axel Thran, Torjus Skajaa, Ronald E Gordon, Jens-Peter Schlomka, Valentin Fuster, Edward A Fisher, Willem J M Mulder, Roland Proksa, Zahi A Fayad. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20668118\/\">Atherosclerotic plaque composition: analysis with multicolor CT and targeted gold nanoparticles<\/a>. Radiology. 2010 Sep;256(3):774-82.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Multicolour CT and gold nanoparticles for evaluation of plaque. Multicolor CT is the popular name for spectral computed tomography. <\/p>\n","protected":false},"author":1,"featured_media":36815,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[19],"tags":[120,412,736,1598,1599,1600,1601,2274,2498,3642,3643,4135],"class_list":["post-4783","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiac-ct-scan","tag-acute-coronary-syndrome","tag-au-hdl","tag-characterization-of-macrophage-burden","tag-gold-high-density-nanoparticle-contrast-agent","tag-gold-nanoparticles","tag-gold-nanoparticles-for-evaluation-of-plaque","tag-gold-nanoparticles-were-located-primarily-in-the-macrophages","tag-macrophage-rich-plaques","tag-multicolour-ct","tag-spectral-computed-tomography","tag-spectral-ct-system","tag-vascular-events"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Multicolour CT and gold nanoparticles for evaluation of plaque<\/title>\n<meta name=\"description\" content=\"Multicolour CT and gold nanoparticles for evaluation of plaque. Multicolor CT is the popular name for spectral computed tomography.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Multicolour CT and gold nanoparticles for evaluation of plaque\" \/>\n<meta property=\"og:description\" content=\"Multicolour CT and gold nanoparticles for evaluation of plaque. Multicolor CT is the popular name for spectral computed tomography.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2010-08-20T15:19:48+00:00\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"Multicolour CT and gold nanoparticles for evaluation of plaque\",\"datePublished\":\"2010-08-20T15:19:48+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque\\\/\"},\"wordCount\":237,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"keywords\":[\"Acute coronary syndrome\",\"Au-HDL\",\"characterization of macrophage burden\",\"Gold high density nanoparticle contrast agent\",\"gold nanoparticles\",\"gold nanoparticles for evaluation of plaque\",\"Gold nanoparticles were located primarily in the macrophages\",\"Macrophage rich plaques\",\"Multicolour CT\",\"spectral computed tomography\",\"spectral CT system\",\"vascular events\"],\"articleSection\":[\"Cardiac CT scan\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque\\\/\",\"name\":\"Multicolour CT and gold nanoparticles for evaluation of plaque\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/multicolour-ct-and-gold-nanoparticles-for-evaluation-of-plaque\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"datePublished\":\"2010-08-20T15:19:48+00:00\",\"description\":\"Multicolour CT and gold nanoparticles for evaluation of plaque. 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