{"id":5343,"date":"2010-09-30T13:39:33","date_gmt":"2010-09-30T13:39:33","guid":{"rendered":"http:\/\/cardiophile.org\/?p=5343"},"modified":"2010-09-30T13:39:33","modified_gmt":"2010-09-30T13:39:33","slug":"genetic-basis-for-wpw-syndrome","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/genetic-basis-for-wpw-syndrome\/","title":{"rendered":"Genetic basis for WPW syndrome"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/f7FRsEMogdY\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\"><\/iframe><\/p>\n<h2><span style=\"color: #008000;\">Genetic basis for WPW syndrome<\/span><\/h2>\n<p>Genetic basis for WPW syndrome: Not all cases of WPW syndrome may have a genetic basis. One of the genes to be implicated first in WPW syndrome was&nbsp; PRKAG2 gene which encodes for the gamma-2 regulatory subunit of AMP-activated protein kinase. The enzyme functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Mutations in the gene causes distortion of the atrioventricular annulus by glycogen-filled myocytes and causes ventricular pre-excitation. The gene location has been given as 7q36.1 in the <a href=\"https:\/\/omim.org\/entry\/194200\">OMIM (Online Mendelian Inheritance in Man<\/a>\u00ae) database<span style=\"font-size: inherit;\">.<\/span><\/p>\n<p>BMP2 was another gene which has been linked with WPW syndrome by S R Lalani, J V Thakuria, G F Cox, X Wang, W Bi, M S Bray, C Shaw, S W Cheung, A C Chinault, B A Boggs, Z Ou, E K Brundage, J R Lupski, J Gentile, S Waisbren, A Pursley, L Ma, M Khajavi, G Zapata, R Friedman, J J Kim, J A Towbin, P Stankiewicz, S Schnittger, I Hansmann, T Ai, S Sood, X H Wehrens, J F Martin and J W Belmont, L Potocki [1]. Bone morphogenetic protein is involved in the development of the atrioventricular canal. Microdeletion of 20p12.3 produces pre-excitation (Wolff-Parkinson-White syndrome) along with variable neurocognitive deficits.<\/p>\n<p><span style=\"color: #0000ff;\"><strong>Reference<\/strong><\/span><\/p>\n<ol>\n<li>S R Lalani, J V Thakuria, G F Cox, X Wang, W Bi, M S Bray, C Shaw, S W Cheung, A C Chinault, B A Boggs, Z Ou, E K Brundage, J R Lupski, J Gentile, S Waisbren, A Pursley, L Ma, M Khajavi, G Zapata, R Friedman, J J Kim, J A Towbin, P Stankiewicz, S Schnittger, I Hansmann, T Ai, S Sood, X H Wehrens, J F Martin, J W Belmont, L Potocki. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18812404\">20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits.<\/a>&nbsp;J Med Genet 2009;46:168 \u201375.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>PRKAG2 gene which encodes for the gamma-2 regulatory subunit of AMP-activated protein kinase and BMP2 have been implicated in to WPW syndrome.<\/p>\n","protected":false},"author":1,"featured_media":38946,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-5343","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ecg-electrophysiology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Genetic basis for WPW syndrome<\/title>\n<meta name=\"description\" content=\"Genetic basis for WPW syndrome: PRKAG2 gene which encodes for the gamma-2 regulatory subunit of AMP-activated protein kinase and BMP2 have been implicated in to WPW syndrome.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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