{"id":56780,"date":"2022-11-21T04:13:13","date_gmt":"2022-11-20T22:43:13","guid":{"rendered":"https:\/\/johnsonfrancis.org\/professional\/?p=56780"},"modified":"2022-11-21T04:13:15","modified_gmt":"2022-11-20T22:43:15","slug":"digoxin-amiodarone-interaction","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/digoxin-amiodarone-interaction\/","title":{"rendered":"Digoxin amiodarone interaction"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/gNJrVB_bM9w\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\"><\/iframe><\/p>\n<h2><span style=\"color: #008000;\">Digoxin amiodarone interaction<\/span><\/h2>\n<p>Important drugs which can increase the levels of digoxin are quinidine, verapamil, amiodarone and dronedarone [1]. The dose of digoxin should be halved with concomitant use of verapamil, amiodarone or dronedarone. Drugs with high levels of protein binding displace digoxin from protein binding sites and increase the effective blood levels of digoxin. Monitoring of plasma digoxin levels and frequent evaluation for signs and symptoms of digoxin toxicity are recommended while using these drugs in combination with digoxin, when that combination is deemed essential.<\/p>\n<p>Another reason for caution while combining digoxin and amiodarone is that both drugs can slow the atrioventricular (AV) conduction. But as the use of digoxin is fast waning, these concerns are not very often seen in the current scenario.<\/p>\n<p><span style=\"color: #0000ff;\"><strong>Reference<\/strong><\/span><\/p>\n<ol>\n<li>Smith H, Battjes E, Yan S, Kaakeh Y. Chronic Digoxin Toxicity Precipitated by Dronedarone.&nbsp;Ann Pharmacother. 2014 Mar 31;48(7):923-927.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Digoxin amiodarone interaction Important drugs which can increase the levels of digoxin are quinidine, verapamil, amiodarone and dronedarone [1]. The dose of digoxin should be halved with concomitant use of verapamil, amiodarone or dronedarone. Drugs with high levels of protein binding displace digoxin from protein binding sites and increase the effective blood levels of digoxin. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-56780","post","type-post","status-publish","format-standard","hentry","category-general"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Digoxin amiodarone interaction - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/digoxin-amiodarone-interaction\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Digoxin amiodarone interaction - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"Digoxin amiodarone interaction Important drugs which can increase the levels of digoxin are quinidine, verapamil, amiodarone and dronedarone [1]. The dose of digoxin should be halved with concomitant use of verapamil, amiodarone or dronedarone. Drugs with high levels of protein binding displace digoxin from protein binding sites and increase the effective blood levels of digoxin. 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