{"id":56893,"date":"2022-11-24T19:39:19","date_gmt":"2022-11-24T14:09:19","guid":{"rendered":"https:\/\/johnsonfrancis.org\/professional\/?p=56893"},"modified":"2022-11-26T07:08:55","modified_gmt":"2022-11-26T01:38:55","slug":"what-is-the-role-of-disopyramide-in-hcm","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/what-is-the-role-of-disopyramide-in-hcm\/","title":{"rendered":"What is the role of Disopyramide in HCM?"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/beHx23dAzTU\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\"><\/iframe><\/p>\n<h2><span style=\"color: #008000;\">What is the role of Disopyramide in HCM?<\/span><\/h2>\n<p>Disopyramide is a class Ia antiarrhythmic agent which can be used in hypertrophic obstructive cardiomyopathy when beta blockers alone are ineffective. Disopyramide has a negative inotropic action and is useful in reducing left ventricular outflow tract gradients in hypertrophic obstructive cardiomyopathy and does not increase the risk of sudden cardiac death. Dose reduction is recommended when QTc exceeds 480 ms. It should be avoided in those with glaucoma and men with prostatic symptoms in view of its anticholinergic action. Anticholinergic action is responsible for increase in ventricular rate with atrial fibrillation. It can be combined with verapamil.<\/p>\n<p align=\"LEFT\">An important downside is that it is not available in most countries! Anticholinergic symptoms like dryness of mouth and eyes, urinary hesitancy or retention and constipation may limit the dose up titration.<\/p>\n<p align=\"LEFT\"><span style=\"color: #0000ff;\"><strong>Reference<\/strong><\/span><\/p>\n<p align=\"LEFT\">1. Elliott PM, Anastasakis A, Borger MA, Borggrefe M, Cecchi F, Charron P, Hagege AA, Lafont A, Limongelli G, Mahrholdt H, McKenna WJ, Mogensen J, Nihoyannopoulos P, Nistri S, Pieper PG, Pieske B, Rapezzi C, Rutten FH, Tillmanns C, Watkins H. 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). Eur Heart J. 2014 Oct 14;35(39):2733-79.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is the role of Disopyramide in HCM? Disopyramide is a class Ia antiarrhythmic agent which can be used in hypertrophic obstructive cardiomyopathy when beta blockers alone are ineffective. Disopyramide has a negative inotropic action and is useful in reducing left ventricular outflow tract gradients in hypertrophic obstructive cardiomyopathy and does not increase the risk [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":56926,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-56893","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is the role of Disopyramide in HCM? - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/what-is-the-role-of-disopyramide-in-hcm\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is the role of Disopyramide in HCM? - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"What is the role of Disopyramide in HCM? Disopyramide is a class Ia antiarrhythmic agent which can be used in hypertrophic obstructive cardiomyopathy when beta blockers alone are ineffective. Disopyramide has a negative inotropic action and is useful in reducing left ventricular outflow tract gradients in hypertrophic obstructive cardiomyopathy and does not increase the risk [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/what-is-the-role-of-disopyramide-in-hcm\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-24T14:09:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-11-26T01:38:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/johnsonfrancis.org\/professional\/wp-content\/uploads\/2022\/11\/What-is-the-role-of-Disopyramide-in-HCM.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1201\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/what-is-the-role-of-disopyramide-in-hcm\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/what-is-the-role-of-disopyramide-in-hcm\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"What is the role of Disopyramide in HCM?\",\"datePublished\":\"2022-11-24T14:09:19+00:00\",\"dateModified\":\"2022-11-26T01:38:55+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/what-is-the-role-of-disopyramide-in-hcm\\\/\"},\"wordCount\":217,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/what-is-the-role-of-disopyramide-in-hcm\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/wp-content\\\/uploads\\\/2022\\\/11\\\/What-is-the-role-of-Disopyramide-in-HCM.jpg\",\"articleSection\":[\"General Cardiology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/what-is-the-role-of-disopyramide-in-hcm\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/what-is-the-role-of-disopyramide-in-hcm\\\/\",\"name\":\"What is the role of Disopyramide in HCM? 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