{"id":57290,"date":"2022-12-06T06:25:49","date_gmt":"2022-12-06T00:55:49","guid":{"rendered":"https:\/\/johnsonfrancis.org\/professional\/?p=57290"},"modified":"2022-12-06T06:25:51","modified_gmt":"2022-12-06T00:55:51","slug":"pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus\/","title":{"rendered":"Pharmacological closure and maintaining patency of ductus arteriosus"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/phhIirp3geY\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\"><\/iframe><\/p>\n<h2><span style=\"color: #008000;\">Pharmacological closure and maintaining patency of ductus arteriosus<\/span><\/h2>\n<div>\n<p>Prostaglandin E1 is used for maintaining ductal patency in ductus dependent circulations [1]. Both oral [2] and intravenous paracetamol [3] have been used for <em>pharmacological closure of patent ductus arteriosus<\/em> in newborns. Indomethacin was the earlier drug being used for pharmacological ductal closure, but seldom used now because of its adverse effects. Then came ibuprofen, which is still being used. Paracetamol is the latest addition, with a better side effect profile than ibuprofen.<\/p>\n<\/div>\n<div>Ductus dependent circulations are classified into ductus dependent pulmonary circulations and ductus dependent systemic circulations. Both worsen after birth at the time of spontaneous ductal closure.<\/div>\n<p><span style=\"color: #0000ff;\"><b>References<\/b><\/span><\/p>\n<p>1. Huang FK, Lin CC, Huang TC, Weng KP, Liu PY, Chen YY, Wang HP, Ger LP, Hsieh KS. Reappraisal of the prostaglandin E1 dose for early newborns with patent ductus arteriosus-dependent pulmonary circulation. Pediatr Neonatol. 2013 Apr;54(2):102-6.<br \/>\n2. Bagheri MM, Niknafs P, Sabsevari F, Torabi MH, Bahman Bijari B, Noroozi E, Mossavi H. Comparison of Oral Acetaminophen Versus Ibuprofen in Premature Infants With Patent Ductus Arteriosus. Iran J Pediatr. 2016 May 15;26(4):e3975.<br \/>\n3. Valerio E, Valente MR, Salvadori S, Frigo AC, Baraldi E, Lago P. Intravenous paracetamol for PDA closure in the preterm: a single-center experience. Eur J Pediatr. 2016 Jul;175(7):953-66.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pharmacological closure and maintaining patency of ductus arteriosus Prostaglandin E1 is used for maintaining ductal patency in ductus dependent circulations [1]. Both oral [2] and intravenous paracetamol [3] have been used for pharmacological closure of patent ductus arteriosus in newborns. Indomethacin was the earlier drug being used for pharmacological ductal closure, but seldom used now [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":57291,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-57290","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pharmacological closure and maintaining patency of ductus arteriosus - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pharmacological closure and maintaining patency of ductus arteriosus - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"Pharmacological closure and maintaining patency of ductus arteriosus Prostaglandin E1 is used for maintaining ductal patency in ductus dependent circulations [1]. Both oral [2] and intravenous paracetamol [3] have been used for pharmacological closure of patent ductus arteriosus in newborns. Indomethacin was the earlier drug being used for pharmacological ductal closure, but seldom used now [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-06T00:55:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-12-06T00:55:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/johnsonfrancis.org\/professional\/wp-content\/uploads\/2022\/12\/Pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1211\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"Pharmacological closure and maintaining patency of ductus arteriosus\",\"datePublished\":\"2022-12-06T00:55:49+00:00\",\"dateModified\":\"2022-12-06T00:55:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus\\\/\"},\"wordCount\":211,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/Pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus.jpg\",\"articleSection\":[\"General Cardiology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/pharmacological-closure-and-maintaining-patency-of-ductus-arteriosus\\\/\",\"name\":\"Pharmacological closure and maintaining patency of ductus arteriosus - 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