{"id":64741,"date":"2025-09-19T05:56:13","date_gmt":"2025-09-19T00:26:13","guid":{"rendered":"https:\/\/johnsonfrancis.org\/professional\/?p=64741"},"modified":"2025-09-19T05:56:15","modified_gmt":"2025-09-19T00:26:15","slug":"nongenomic-effects-of-aldosterone","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/nongenomic-effects-of-aldosterone\/","title":{"rendered":"Nongenomic effects of aldosterone"},"content":{"rendered":"<iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/ZG3Vv2J6FI8?si=zWeUsNybEdRWejUm\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n\n<p class=\"wp-block-paragraph\">Genomic effects of aldosterone are those at the nuclear level through transcription after binding to mineralocorticoid receptors. Effects on mineralocorticoid receptors other than those on the nucleus are nongenomic. Nongenomic effects of aldosterone can also involve other receptors like the G-protein-coupled estrogen receptor (GPER), which is responsible for increase in LDL receptors, decrease in LDL cholesterol, decrease in gluconeogenesis, decrease in lipogenesis and decreased triglyceride storage. Other effects through GPER are vasodilatation due to endothelial nitric oxide, increase in apoptosis, decrease in vascular remodeling, vascular injury and cell proliferation and migration [1]. Other nongenomic effects are increases in reactive oxidative species, increased calcium levels, inflammation, elastin production and the regulation of sodium and pH. Nongenomic pathways are rapid acting through caveolin-1, striatin and activation of GPER and extracellular signal-related protein kinase 1 or 2 [2]. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Reference<\/strong>s<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li class=\"\">Fioretti F, Testani JM, Tio MC, Pitt B, Butler J. Aldosterone and Aldosterone Modulation in Cardio-Kidney Diseases. J Am Coll Cardiol. 2025 Aug 5;86(5):354-373. doi: 10.1016\/j.jacc.2025.06.012. PMID: 40738563.<\/li>\n\n\n\n<li class=\"\">Dooley R, Harvey BJ, Thomas W. Non-genomic actions of aldosterone: from receptors and signals to membrane targets. Mol Cell Endocrinol. 2012 Mar 24;350(2):223-34. doi: 10.1016\/j.mce.2011.07.019. Epub 2011 Jul 27. PMID: 21801805.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Genomic effects of aldosterone are those at the nuclear level through transcription after binding to mineralocorticoid receptors. Effects on mineralocorticoid receptors other than those on the nucleus are nongenomic. Nongenomic effects of aldosterone can also involve other receptors like the G-protein-coupled estrogen receptor (GPER), which is responsible for increase in LDL receptors, decrease in LDL [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":64747,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-64741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nongenomic effects of aldosterone - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/nongenomic-effects-of-aldosterone\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nongenomic effects of aldosterone - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"Genomic effects of aldosterone are those at the nuclear level through transcription after binding to mineralocorticoid receptors. Effects on mineralocorticoid receptors other than those on the nucleus are nongenomic. Nongenomic effects of aldosterone can also involve other receptors like the G-protein-coupled estrogen receptor (GPER), which is responsible for increase in LDL receptors, decrease in LDL [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/nongenomic-effects-of-aldosterone\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2025-09-19T00:26:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-19T00:26:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/johnsonfrancis.org\/professional\/wp-content\/uploads\/2025\/09\/Nongenomic-Effects-of-Aldosterone.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1201\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/nongenomic-effects-of-aldosterone\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/nongenomic-effects-of-aldosterone\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"Nongenomic effects of aldosterone\",\"datePublished\":\"2025-09-19T00:26:13+00:00\",\"dateModified\":\"2025-09-19T00:26:15+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/nongenomic-effects-of-aldosterone\\\/\"},\"wordCount\":191,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/nongenomic-effects-of-aldosterone\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/Nongenomic-Effects-of-Aldosterone.jpg\",\"articleSection\":[\"General Cardiology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/nongenomic-effects-of-aldosterone\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/nongenomic-effects-of-aldosterone\\\/\",\"name\":\"Nongenomic effects of aldosterone - 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