{"id":64860,"date":"2025-10-19T17:16:56","date_gmt":"2025-10-19T11:46:56","guid":{"rendered":"https:\/\/johnsonfrancis.org\/professional\/?p=64860"},"modified":"2025-10-19T17:17:00","modified_gmt":"2025-10-19T11:47:00","slug":"is-vigorous-exercise-safe-in-those-with-congenital-long-qt-syndrome","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/is-vigorous-exercise-safe-in-those-with-congenital-long-qt-syndrome\/","title":{"rendered":"Is vigorous exercise safe in those with congenital long QT syndrome?"},"content":{"rendered":"<iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/1X4PNEM3_w4?si=sx2prbMgf1Nr46mG\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n\n<p class=\"wp-block-paragraph\">Here is a carefully worded reply from the authors of Multinational LIVE-LQTS Study [1]: &#8220;Among individuals diagnosed with phenotypic and\/or genotypic LQTS who were risk assessed and treated in experienced centers, LQTS-associated cardiac event rates were low and similar between those exercising vigorously and those not exercising vigorously&#8221;. LIVE-LQTS study (Lifestyle and Exercise in the Long QT Syndrome) was funded by the National Institutes of Health and enrolled individuals between the ages of 8 to 60 years with phenotypic and\/or genotypic long QT syndrome. Thirty seven sites from 5 countries participated during a period of about four years. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vigorous exercise was defined as \u22656 metabolic equivalents for >60 hours per year. Physical activity and clinical events surveys every 6 months for 3 years with follow-up was completed in February 2022. Composite end point included sudden death, sudden cardiac arrest, ventricular arrhythmia treated by an implantable cardioverter defibrillator, and likely arrhythmic syncope. Events were adjudicated by a blinded Clinical Events Committee. Survival status of those with incomplete follow up was ascertained by searching National Death Index.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Of the 1413 participants, two thirds were females. 13% were below the age of 18 years and 35% between the ages of 18 and 25 years. Implantable defibrillators were there in one fourth of the group. 90% were genotype positive and 49% had LQT1. 91% were treated with beta-blockers, left cardiac sympathetic denervation, and\/or implantable cardioverter defibrillator. Interestingly, 52% participated in vigorous exercise, of which 55% were participating in competitive exercise. Thirty seven individuals experienced the composite endpoint. One sudden cardiac arrest and one sudden death occurred in the nonvigorous group while one sudden cardiac arrest occurred in the vigorous group. The overall event rate at 3 years was 2.6% in the vigorous exercise group and 2.7% in the nonvigorous exercise group. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Findings were similar in vigorous-competitive athletes between the ages of 14 to 22 years. Informed and shared decision making discussions between patient and physician about exercise and participation in competitive sports is needed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Reference<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li class=\"\">Lampert R, Day S, Ainsworth B, Burg M, Marino BS, Salberg L, Tome Esteban MT, Abrams DJ, Aziz PF, Barth C, Behr ER, Bell C, Berul CI, Bos JM, Bradley D, Cannom DS, Cannon BC, Concannon MA, Cerrone M, Czosek RJ, Dubin AM, Dziura J, Erickson CC, Estes NAM 3rd, Etheridge SP, Goldenberg I, Gray B, Haglund-Turnquist C, Harmon K, James CA, Johnsrude C, Kannankeril P, Lara A, Law IH, Li F, Link MS, Molossi SM, Olshansky B, Noseworthy PA, Saarel EV, Sanatani S, Shah M, Simone L, Skinner J, Tomaselli GF, Ware JS, Webster G, Zareba W, Zipes DP, Ackerman MJ. Vigorous Exercise in Patients With Congenital Long QT Syndrome: Results of the Prospective, Observational, Multinational LIVE-LQTS Study. Circulation. 2024 Aug 13;150(7):516-530. doi: 10.1161\/CIRCULATIONAHA.123.067590. Epub 2024 Jul 25. PMID: 39051104.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Here is a carefully worded reply from the authors of Multinational LIVE-LQTS Study [1]: &#8220;Among individuals diagnosed with phenotypic and\/or genotypic LQTS who were risk assessed and treated in experienced centers, LQTS-associated cardiac event rates were low and similar between those exercising vigorously and those not exercising vigorously&#8221;. LIVE-LQTS study (Lifestyle and Exercise in the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":64862,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-64860","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Is vigorous exercise safe in those with congenital long QT syndrome? - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/is-vigorous-exercise-safe-in-those-with-congenital-long-qt-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Is vigorous exercise safe in those with congenital long QT syndrome? - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"Here is a carefully worded reply from the authors of Multinational LIVE-LQTS Study [1]: &#8220;Among individuals diagnosed with phenotypic and\/or genotypic LQTS who were risk assessed and treated in experienced centers, LQTS-associated cardiac event rates were low and similar between those exercising vigorously and those not exercising vigorously&#8221;. 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