{"id":6628,"date":"2011-07-31T22:34:49","date_gmt":"2011-07-31T17:04:49","guid":{"rendered":"http:\/\/cardiophile.org\/?p=6628"},"modified":"2011-07-31T22:34:49","modified_gmt":"2011-07-31T17:04:49","slug":"familial-atrial-fibrillation","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/familial-atrial-fibrillation\/","title":{"rendered":"Familial atrial fibrillation"},"content":{"rendered":"

Familial atrial fibrillation<\/span><\/h2>\n

Eighteen types of familial atrial fibrillation (AF) has been described in the OMIM<\/a> (Online Mendelian Inheritance in Man) database.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Type of AF<\/td>\nChromosome<\/td>\nGene<\/td>\n<\/tr>\n
ATFB1<\/td>\n10q22-q24<\/td>\n\u00a0<\/td>\n<\/tr>\n
ATFB2<\/td>\n6q<\/td>\n\u00a0<\/td>\n<\/tr>\n
ATFB3<\/td>\n11<\/td>\nKCNQ1<\/td>\n<\/tr>\n
ATFB4<\/td>\n21<\/td>\nKCNE2<\/td>\n<\/tr>\n
ATFB5<\/td>\n4q25<\/td>\n\u00a0<\/td>\n<\/tr>\n
ATFB6<\/td>\n1p36-p35<\/td>\nNPPA<\/td>\n<\/tr>\n
ATFB7<\/td>\n12p13<\/td>\nKCNA5<\/td>\n<\/tr>\n
ATFB8<\/td>\n16q22<\/td>\n\u00a0<\/td>\n<\/tr>\n
ATFB9<\/td>\n17q24.3<\/td>\nKCNJ2<\/td>\n<\/tr>\n
ATFB10<\/td>\n3p21<\/td>\nSCN5A<\/td>\n<\/tr>\n
ATFB11<\/td>\n1q21.1<\/td>\nGJA5<\/td>\n<\/tr>\n
ATFB12<\/td>\n12p12.1<\/td>\nABCC9<\/td>\n<\/tr>\n
ATFB13<\/td>\n19q13.11<\/td>\nSCN1B<\/td>\n<\/tr>\n
ATFB14<\/td>\n11q23.3<\/td>\nSCN2B<\/td>\n<\/tr>\n
ATFB15<\/td>\n5p13.2<\/td>\nNUP155<\/td>\n<\/tr>\n
ATFB16 (BRGDA7)<\/td>\n11q24.1<\/td>\nSCN3B<\/td>\n<\/tr>\n
ATFB17 (LQT10)<\/td>\n11q23.3<\/td>\nSCN4B<\/td>\n<\/tr>\n
ATFB18<\/td>\n17q21.32<\/td>\nMYL4<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

One of the early reports identifying a genetic locus for familial AF was by R Brugada, T Tapscott, G Z Czernuszewicz, A J Marian, A Iglesias, L Mont, J Brugada, J Girona, A Domingo, L L Bachinski and R Roberts [1], in which ten members spanning over three generations had an autosomal dominant pattern. Nine of them had chronic atrial fibrillation while one had paroxysmal atrial fibrillation.<\/p>\n

It may be noted that gene for ATFB16 is same as that for BRGA7. That for ATFB17 is the same as that for LQT10. These are heterozygous mutations.<\/p>\n

Reference<\/strong><\/span><\/p>\n

    \n
  1. R Brugada, T Tapscott, G Z Czernuszewicz, A J Marian, A Iglesias, L Mont, J Brugada, J Girona, A Domingo, L L Bachinski, R Roberts. Identification of a genetic locus for familial atrial fibrillation<\/a>. N Engl J Med. 1997 Mar 27;336(13):905-11.<\/li>\n<\/ol>\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    Twelve types of familial atrial fibrillation has been described in the OMIM (Online Mendelian Inheritance in Man) database.<\/p>\n","protected":false},"author":1,"featured_media":36280,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-6628","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ecg-electrophysiology"],"yoast_head":"\nFamilial atrial fibrillation<\/title>\n<meta name=\"description\" content=\"Eighteen types of familial atrial fibrillation has been described in the OMIM (Online Mendelian Inheritance in Man) database.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/familial-atrial-fibrillation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" 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