{"id":6938,"date":"2012-04-22T08:59:12","date_gmt":"2012-04-22T08:59:12","guid":{"rendered":"http:\/\/cardiophile.org\/?p=6938"},"modified":"2012-04-22T08:59:12","modified_gmt":"2012-04-22T08:59:12","slug":"drug-eluting-stents-better-for-svg-disease-isar-cabg-trial","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/drug-eluting-stents-better-for-svg-disease-isar-cabg-trial\/","title":{"rendered":"Drug eluting stents better for SVG disease: ISAR-CABG trial"},"content":{"rendered":"

Drug eluting stents better for SVG disease: ISAR-CABG trial<\/span><\/h2>\n

Drug eluting stents better for SVG disease: ISAR-CABG trial: There was a concept that bare metal stents may fare equally well for saphenous vein graft disease as these are large conduits. ISAR-CABG was designed as a superiority trial to compare drug eluting stents with bare metal stents for saphenous vein graft lesions [1]. Three types of drug eluting stents (permanent-polymer paclitaxel-eluting stents, permanent-polymer sirolimus-eluting stents, or biodegradable-polymer sirolimus-eluting stents) or bare-metal stents were used in a ratio of 1:1:1:3. Total of 303 patients received drug-eluting stents and 307 patients received bare-metal stents. The combined incidence of death, myocardial infarction, and target lesion revascularization at 1 year was taken as the primary end point. The primary endpoint was noted in 15% in the drug eluting stent group and 22% in the bare metal stent group. Target lesion revascularization rate was lower for drug-eluting stents (7% vs 13%). There was no difference in the all cause mortality, which was 5% in each group and stent thrombosis was also similar, at 1%. The authors concluded that for de-novo saphenous vein graft lesions, drug eluting stents were better than bare metal stents.<\/p>\n

Reference<\/strong><\/span><\/p>\n

    \n
  1. Julinda Mehilli, J\u00fcrgen Pache, Mohamed Abdel-Wahab, Stefanie Schulz, Robert A Byrne, Klaus Tiroch, J\u00f6rg Hausleiter, Melchior Seyfarth, Ilka Ott, Tareq Ibrahim, Massimiliano Fusaro, Karl-Ludwig Laugwitz, Steffen Massberg, Franz-Josef Neumann, Gert Richardt, Albert Sch\u00f6mig, Adnan Kastrati, Is Drug-Eluting-Stenting Associated with Improved Results in Coronary Artery Bypass Grafts? (ISAR-CABG) Investigators. Drug-eluting versus bare-metal stents in saphenous vein graft lesions (ISAR-CABG): a randomised controlled superiority trial.<\/a>\u00a0Lancet. 2011 Sep 17;378(9796):1071-8.<\/li>\n<\/ol>\n
    <\/div>\n","protected":false},"excerpt":{"rendered":"

    ISAR-CABG trial: for de-novo saphenous vein graft lesions, drug eluting stents were better than bare metal stents.<\/p>\n","protected":false},"author":1,"featured_media":38354,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[18],"tags":[],"class_list":["post-6938","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-angiography-and-interventions"],"yoast_head":"\nDrug eluting stents better for SVG disease: ISAR-CABG trial<\/title>\n<meta name=\"description\" content=\"Drug eluting stents better for SVG disease: ISAR-CABG trial: for de-novo SVG lesions, drug eluting stents were better than bare metal stents.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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