{"id":7165,"date":"2012-04-22T14:29:15","date_gmt":"2012-04-22T14:29:15","guid":{"rendered":"http:\/\/cardiophile.org\/?p=7165"},"modified":"2012-04-22T14:29:15","modified_gmt":"2012-04-22T14:29:15","slug":"decellularized-pulmonary-homograft","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/","title":{"rendered":"Decellularized pulmonary homograft"},"content":{"rendered":"

Decellularized pulmonary homograft<\/span><\/h2>\n

Decellularized pulmonary homograft is an allograft recovered from cadavers and specially processed to remove cells so that what remains is a scaffold of connective tissue. It is less likely to initiate an immune response and allograft rejection process. A recent study by Serghei Cebotari, Igor Tudorache, Anatol Ciubotaru, Dietmar Boethig, Samir Sarikouch, Adelheid Goerler, Artur Lichtenberg, Eduard Cheptanaru, Sergiu Barnaciuc, Anatol Cazacu, Oxana Maliga, Oleg Repin, Liviu Maniuc, Thomas Breymann and Axel Haverich [1] compared fresh decellularized pulmonary homografts with glutaraldehyde-fixed bovine jugular valve and cryopreserved homografts.<\/p>\n

Echocardiography did not show increase of transvalvular gradient, cusp thickening, or aneurysmatic dilatation with decellularized homograft. Decellularized pulmonary homograft valve annulus showed adaptive growth with z-values which tended towards normal. There were no explantations on five year follow up in the study group while it was needed in twelve to fourteen percent of cases in the groups implanted with bovine jugular valve and cryopreserved homografts. While the mean transvalvar gradient was eleven millimeter of mercury in the decellularized pulmonary homograft group, it was twenty three millimeters of mercury in the bovine jugular valve group. Of the thirty eight person who had the homografts implanted three had moderate regurgitation, which remained static on follow up.<\/p>\n

Reference<\/strong><\/span><\/p>\n

    \n
  1. Serghei Cebotari, Igor Tudorache, Anatol Ciubotaru, Dietmar Boethig, Samir Sarikouch, Adelheid Goerler, Artur Lichtenberg, Eduard Cheptanaru, Sergiu Barnaciuc, Anatol Cazacu, Oxana Maliga, Oleg Repin, Liviu Maniuc, Thomas Breymann, Axel Haverich. Use of Fresh Decellularized Allografts for Pulmonary Valve Replacement May Reduce the Reoperation Rate in Children and Young Adults.<\/a>\u00a0Circulation. 2011; 124: S115-S123.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Decellularized pulmonary homograft is a cadaver derived allograft, processed to remove cells so that what remains is a scaffold of connective tissue. <\/p>\n","protected":false},"author":1,"featured_media":39314,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[22],"tags":[],"class_list":["post-7165","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cardiac-surgery"],"yoast_head":"\nDecellularized pulmonary homograft - processed to remove cells<\/title>\n<meta name=\"description\" content=\"Decellularized pulmonary homograft is a cadaver derived allograft, processed to remove cells so that a scaffold of connective tissue remains.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Decellularized pulmonary homograft - processed to remove cells\" \/>\n<meta property=\"og:description\" content=\"Decellularized pulmonary homograft is a cadaver derived allograft, processed to remove cells so that a scaffold of connective tissue remains.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2012-04-22T14:29:15+00:00\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"Decellularized pulmonary homograft\",\"datePublished\":\"2012-04-22T14:29:15+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/\"},\"wordCount\":259,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"articleSection\":[\"Cardiac Surgery\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/\",\"name\":\"Decellularized pulmonary homograft - processed to remove cells\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"datePublished\":\"2012-04-22T14:29:15+00:00\",\"description\":\"Decellularized pulmonary homograft is a cadaver derived allograft, processed to remove cells so that a scaffold of connective tissue remains.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/#primaryimage\",\"url\":\"\",\"contentUrl\":\"\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/decellularized-pulmonary-homograft\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Decellularized pulmonary homograft\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\",\"name\":\"All About Cardiovascular System and Disorders\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\",\"name\":\"Johnson Francis\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"caption\":\"Johnson Francis\"},\"logo\":{\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\"},\"description\":\"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/author\\\/jf\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Decellularized pulmonary homograft - processed to remove cells","description":"Decellularized pulmonary homograft is a cadaver derived allograft, processed to remove cells so that a scaffold of connective tissue remains.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/","og_locale":"en_US","og_type":"article","og_title":"Decellularized pulmonary homograft - processed to remove cells","og_description":"Decellularized pulmonary homograft is a cadaver derived allograft, processed to remove cells so that a scaffold of connective tissue remains.","og_url":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/","og_site_name":"All About Cardiovascular System and Disorders","article_published_time":"2012-04-22T14:29:15+00:00","author":"Johnson Francis","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Johnson Francis","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/#article","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/"},"author":{"name":"Johnson Francis","@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"headline":"Decellularized pulmonary homograft","datePublished":"2012-04-22T14:29:15+00:00","mainEntityOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/"},"wordCount":259,"publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/#primaryimage"},"thumbnailUrl":"","articleSection":["Cardiac Surgery"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/","url":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/","name":"Decellularized pulmonary homograft - processed to remove cells","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#website"},"primaryImageOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/#primaryimage"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/#primaryimage"},"thumbnailUrl":"","datePublished":"2012-04-22T14:29:15+00:00","description":"Decellularized pulmonary homograft is a cadaver derived allograft, processed to remove cells so that a scaffold of connective tissue remains.","breadcrumb":{"@id":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/#primaryimage","url":"","contentUrl":""},{"@type":"BreadcrumbList","@id":"https:\/\/johnsonfrancis.org\/professional\/decellularized-pulmonary-homograft\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/johnsonfrancis.org\/professional\/"},{"@type":"ListItem","position":2,"name":"Decellularized pulmonary homograft"}]},{"@type":"WebSite","@id":"https:\/\/johnsonfrancis.org\/professional\/#website","url":"https:\/\/johnsonfrancis.org\/professional\/","name":"All About Cardiovascular System and Disorders","description":"","publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/johnsonfrancis.org\/professional\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":["Person","Organization"],"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec","name":"Johnson Francis","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","caption":"Johnson Francis"},"logo":{"@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g"},"description":"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal","url":"https:\/\/johnsonfrancis.org\/professional\/author\/jf\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/7165","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/comments?post=7165"}],"version-history":[{"count":0,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/7165\/revisions"}],"wp:attachment":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/media?parent=7165"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/categories?post=7165"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/tags?post=7165"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}