{"id":7306,"date":"2012-04-22T16:07:56","date_gmt":"2012-04-22T16:07:56","guid":{"rendered":"http:\/\/cardiophile.org\/?p=7306"},"modified":"2012-04-22T16:07:56","modified_gmt":"2012-04-22T16:07:56","slug":"celivarone-vs-amiodarone-the-alphee-study","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/celivarone-vs-amiodarone-the-alphee-study\/","title":{"rendered":"Celivarone vs amiodarone \u2013 ALPHEE study"},"content":{"rendered":"

Celivarone vs amiodarone \u2013 ALPHEE study<\/span><\/h2>\n

Celivarone vs amiodarone \u2013 ALPHEE study: ALPHEE study conducted by Peter R Kowey, Harry J G M Crijns, Etienne M Aliot, Alessandro Capucci, Piotr Kulakowski, David Radzik, Denis Roy, Stuart J Connolly and Stefan H Hohnloser, the ALPHEE Study Investigators [1] compared the efficacy and safety of celivarone, a new antiarrhythmic drug with the age old amiodarone. This was a randomized double blind placebo controlled parallel group study of around five hundred patients with left ventricular dysfunction and at least one appropriate implantable cardioverter-defibrillator (ICD) intervention in the previous month for a ventricular tachyarrhythmia. Median duration of treatment was nine months.<\/p>\n

They had evaluated celivarone in doses of 50, 100 and 300 mg and found that none of the comparisons with placebo were statistically significant. Amiodarone<\/a> was used as a calibrator at a dose of 200 mg daily after an initial loading dose of 600 mg daily for 10 days.<\/p>\n

But it had an acceptable safety profile. The authors finally concluded that celivarone was not effective for the prevention of ICD intervention or sudden death.<\/p>\n

Reference<\/span><\/strong><\/p>\n

    \n
  1. Peter R Kowey, Harry J G M Crijns, Etienne M Aliot, Alessandro Capucci, Piotr Kulakowski, David Radzik, Denis Roy, Stuart J Connolly, Stefan H Hohnloser, ALPHEE Study Investigators. Efficacy and Safety of Celivarone, With Amiodarone as Calibrator, in Patients With an Implantable Cardioverter-Defibrillator for Prevention of Implantable Cardioverter-Defibrillator Interventions or Death<\/a>. Circulation. 2011 Dec 13;124(24):2649-60.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    ALPHEE study concluded that celivarone was not effective for the prevention of ICD intervention or sudden death.<\/p>\n","protected":false},"author":1,"featured_media":35786,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-7306","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ecg-electrophysiology"],"yoast_head":"\nCelivarone vs amiodarone \u2013 the ALPHEE study<\/title>\n<meta name=\"description\" content=\"Celivarone vs amiodarone \u2013 the ALPHEE study concluded that celivarone was not effective for the prevention of ICD intervention or sudden death.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/celivarone-vs-amiodarone-the-alphee-study\/\" 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