{"id":7650,"date":"2012-06-21T12:57:25","date_gmt":"2012-06-21T12:57:25","guid":{"rendered":"http:\/\/cardiophile.org\/?p=7650"},"modified":"2012-06-21T12:57:25","modified_gmt":"2012-06-21T12:57:25","slug":"discontinue-prasugrel-7-days-before-surgery-recovery-trial","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/discontinue-prasugrel-7-days-before-surgery-recovery-trial\/","title":{"rendered":"Discontinue prasugrel 7 days before surgery – Recovery Trial"},"content":{"rendered":"

Discontinue prasugrel 7 days before surgery – Recovery Trial<\/span><\/h2>\n

Discontinue prasugrel 7 days before surgery: Recovery Trial done by Matthew J Price, James S Walder, Brian A Baker, Darell E Heiselman, Joseph A Jakubowski, Douglas K Logan, Kenneth J Winters, Wei Li and Dominick J Angiolillo assessed the platelet reactivity after discontinuation of prasugrel and clopidogrel to see how many prior to surgery, the drug has to be stopped [1].<\/p>\n

Patients on aspirin for coronary artery disease were randomized to either prasugrel 10 mg or clopidogrel 75 mg daily for a period of 7 days. Platelet reactivity was measured before giving the study drug and up to 12 days after drug discontinuation. More than 75 percent of patients returned to baseline platelet reactivity within 7 days after discontinuation of prasugrel while similar effect was achieved within 5 days for clopidogrel. The timing was consistent with the current guidelines for discontinuation of these drugs prior to surgery.<\/p>\n

Reference<\/span><\/strong><\/p>\n

    \n
  1. Matthew J Price, James S Walder, Brian A Baker, Darell E Heiselman, Joseph A Jakubowski, Douglas K Logan, Kenneth J Winters, Wei Li, Dominick J Angiolillo.\u00a0Recovery of Platelet Function After Discontinuation of Prasugrel or Clopidogrel Maintenance Dosing in Aspirin-Treated Patients With Stable Coronary Disease. The Recovery Trial.<\/a>\u00a0J Am Coll Cardiol. 2012 Jun 19;59(25):2338-43.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    More than 75 % of patients returned to baseline platelet reactivity in 7 days after discontinuation of prasugrel, similar effect for clopidogrel in 5 days <\/p>\n","protected":false},"author":1,"featured_media":35066,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-7650","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"\nDiscontinue prasugrel 7 days before surgery - Recovery Trial - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"description\" content=\"More than 75 % of patients returned to baseline platelet reactivity in 7 days after discontinuation of prasugrel, similar effect for clopidogrel in 5 days\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/discontinue-prasugrel-7-days-before-surgery-recovery-trial\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Discontinue prasugrel 7 days before surgery - 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