{"id":8028,"date":"2013-02-21T16:52:26","date_gmt":"2013-02-21T16:52:26","guid":{"rendered":"http:\/\/cardiophile.org\/?p=8028"},"modified":"2013-02-21T16:52:26","modified_gmt":"2013-02-21T16:52:26","slug":"brugada-syndrome-genes","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/brugada-syndrome-genes\/","title":{"rendered":"Brugada Syndrome Genes"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/2o3-T3DXk5g\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\"><\/iframe><\/p>\n<h2><span style=\"color: #008000;\">Brugada syndrome genes<\/span><\/h2>\n<p>Brugada syndrome genes: Brugada syndrome is an inherited arrhythmogenic syndrome with life threatening ventricular arrhythmias, right bundle branch like pattern and ST segment elevation in right precordial leads. The first gene abnormality to be described was in SCN5A, the sodium channel gene. This has been designated as Brugada syndrome 1. <span class=\"mim-text-font\">BRGDA2<\/span> was described as defect in the GPD1L gene. The genetic defect in <span class=\"mim-text-font\">BRGDA<\/span>3 is localized to the calcium channel gene CACNA1C. <span class=\"mim-text-font\">BRGDA<\/span>4 has an abnormality in another calcium channel gene CACNB2. <span class=\"mim-text-font\">BRGDA<\/span>5 has sodium channel gene defect in SCN1B. Potassium channel KCNE3 is defective in <span class=\"mim-text-font\">BRGDA<\/span>6. Sodium channel SCN3B is defective in <span class=\"mim-text-font\">BRGDA<\/span>7. HCN4 defect characterizes <span class=\"mim-text-font\">BRGDA<\/span>8. Mutation in KCND3 has been designated as <span class=\"mim-text-font\">BRGDA<\/span>9 [1]. This is list of designated Brugada syndrome 1 to 9 from the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/omim\/\">OMIM (Online Mendelian Inheritance in Man\u00ae) database on NCBI (National Center for Biotechnology Information).<\/a><\/p>\n<p>The article by <span style=\"line-height: 1.5;\">Ramon Brugada,&nbsp; Oscar Campuzano, Georgia Sarquella-Brugada, Pedro Brugada, Josep Brugada, Kui Hong [2] lists 23 genes: ABCC9, CACNA1C, CACNA2D1, CACNB2, FGF12, GPD1L, HCN4, KCND2, KCND3, KCNE5, KCNE3, KCNH2, KCNJ8, PKP2, RANGRF, SCN1B, SCN2B, SCN3B, SCN5A, SCN10A, SEMA3A, SLMAP, and TRPM4.<\/span><\/p>\n<p><span style=\"color: #0000ff;\"><strong>References<\/strong><\/span><\/p>\n<ol>\n<li>John R Giudicessi, Dan Ye, David J Tester, Lia Crotti, Alessandra Mugione, Vladislav V Nesterenko, Richard M Albertson, Charles Antzelevitch, Peter J Schwartz, Michael J Ackerman. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21349352\/\">Transient Outward Current (I(to)) Gain-Of-Function Mutations in the KCND3-encoded Kv4.3 Potassium Channel and Brugada Syndrome<\/a>. Heart Rhythm. 2011 Jul;8(7):1024-32.<\/li>\n<li><span style=\"line-height: 1.5;\">Ramon Brugada,&nbsp; Oscar Campuzano, Georgia Sarquella-Brugada, Pedro Brugada, Josep Brugada, Kui Hong. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1517\/\">Brugada Syndrome. Synonym: Sudden Unexpected Nocturnal Death Syndrome<\/a>.&nbsp; Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews\u00ae [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2015.<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Brugada syndrome is an inherited arrhythmogenic syndrome with deadly ventricular arrhythmias, RBBB  pattern and ST  elevation in right precordial leads<\/p>\n","protected":false},"author":1,"featured_media":34888,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[6],"tags":[],"class_list":["post-8028","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ecg-electrophysiology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Brugada Syndrome Genes - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"description\" content=\"Brugada syndrome genes: OMIM database has designated 9 genotypes as Brs 1 to BrS 9. 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