{"id":8034,"date":"2013-03-24T06:35:22","date_gmt":"2013-03-24T06:35:22","guid":{"rendered":"http:\/\/cardiophile.org\/?p=8034"},"modified":"2013-03-24T06:35:22","modified_gmt":"2013-03-24T06:35:22","slug":"calmodulin-gene-mutation-producing-life-threatening-qt-prolongation","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/","title":{"rendered":"Calmodulin gene mutation producing life threatening QT prolongation"},"content":{"rendered":"<h2><span style=\"color: #008000;\">Calmodulin gene mutation producing life threatening QT prolongation<\/span><\/h2>\n<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/hSTrMvmHNew\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\"><\/iframe><br \/>\nCalmodulin gene mutation: Lia Crotti, Christopher N Johnson, Elisabeth Graf, Gaetano M De Ferrari, Bettina F Cuneo, Marc Ovadia, John Papagiannis, Michael D Feldkamp, Subodh G Rathi, Jennifer D Kunic, Matteo Pedrazzini, Thomas Wieland, Peter Lichtner, Britt-Maria Beckmann, Travis Clark, Christian Shaffer, D Woodrow Benson, Stefan K\u00e4\u00e4b, Thomas Meitinger, Tim M Strom, Walter J Chazin, Peter J Schwartz and Alfred L George Jr [1], the pioneer in studies on congenital long QT syndrome, have described three denovo mutations in CALM1 and CALM2 mutations associated with QT prolongation and recurrent cardiac arrests in infants. The infants had life threatening ventricular arrhythmias, epilepsy and variable delay in neurodevelopment. There was a several fold decrease in the calcium binding efficacy of the mutant calmodulins. This will affect the calcium signaling in the membrane ion channels of the heart and lead on to deadly arrhythmias.<\/p>\n<p><span style=\"color: #0000ff;\"><strong>Reference<\/strong><\/span><\/p>\n<ol>\n<li>Lia Crotti, Christopher N Johnson, Elisabeth Graf, Gaetano M De Ferrari, Bettina F Cuneo, Marc Ovadia, John Papagiannis, Michael D Feldkamp, Subodh G Rathi, Jennifer D Kunic, Matteo Pedrazzini, Thomas Wieland, Peter Lichtner, Britt-Maria Beckmann, Travis Clark, Christian Shaffer, D Woodrow Benson, Stefan K\u00e4\u00e4b, Thomas Meitinger, Tim M Strom, Walter J Chazin, Peter J Schwartz, Alfred L George Jr.&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23388215\">Calmodulin Mutations Associated With Recurrent Cardiac Arrest in Infants.<\/a>&nbsp;Circulation. 2013 Mar 5;127(9):1009-17.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Calmodulin gene mutation producing life threatening QT prolongation<\/p>\n","protected":false},"author":1,"featured_media":34877,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-8034","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Calmodulin gene mutation producing life threatening QT prolongation - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"description\" content=\"Calmodulin gene mutation mutations in CALM1 and CALM2 are associated with QT prolongation and recurrent cardiac arrests in infants.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Calmodulin gene mutation producing life threatening QT prolongation - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"Calmodulin gene mutation mutations in CALM1 and CALM2 are associated with QT prolongation and recurrent cardiac arrests in infants.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2013-03-24T06:35:22+00:00\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"Calmodulin gene mutation producing life threatening QT prolongation\",\"datePublished\":\"2013-03-24T06:35:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/\"},\"wordCount\":232,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"articleSection\":[\"General Cardiology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/\",\"name\":\"Calmodulin gene mutation producing life threatening QT prolongation - All About Cardiovascular System and Disorders\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/#primaryimage\"},\"thumbnailUrl\":\"\",\"datePublished\":\"2013-03-24T06:35:22+00:00\",\"description\":\"Calmodulin gene mutation mutations in CALM1 and CALM2 are associated with QT prolongation and recurrent cardiac arrests in infants.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/#primaryimage\",\"url\":\"\",\"contentUrl\":\"\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Calmodulin gene mutation producing life threatening QT prolongation\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\",\"name\":\"All About Cardiovascular System and Disorders\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\",\"name\":\"Johnson Francis\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"caption\":\"Johnson Francis\"},\"logo\":{\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\"},\"description\":\"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/author\\\/jf\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Calmodulin gene mutation producing life threatening QT prolongation - All About Cardiovascular System and Disorders","description":"Calmodulin gene mutation mutations in CALM1 and CALM2 are associated with QT prolongation and recurrent cardiac arrests in infants.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/","og_locale":"en_US","og_type":"article","og_title":"Calmodulin gene mutation producing life threatening QT prolongation - All About Cardiovascular System and Disorders","og_description":"Calmodulin gene mutation mutations in CALM1 and CALM2 are associated with QT prolongation and recurrent cardiac arrests in infants.","og_url":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/","og_site_name":"All About Cardiovascular System and Disorders","article_published_time":"2013-03-24T06:35:22+00:00","author":"Johnson Francis","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Johnson Francis","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/#article","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/"},"author":{"name":"Johnson Francis","@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"headline":"Calmodulin gene mutation producing life threatening QT prolongation","datePublished":"2013-03-24T06:35:22+00:00","mainEntityOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/"},"wordCount":232,"publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/#primaryimage"},"thumbnailUrl":"","articleSection":["General Cardiology"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/","url":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/","name":"Calmodulin gene mutation producing life threatening QT prolongation - All About Cardiovascular System and Disorders","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#website"},"primaryImageOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/#primaryimage"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/#primaryimage"},"thumbnailUrl":"","datePublished":"2013-03-24T06:35:22+00:00","description":"Calmodulin gene mutation mutations in CALM1 and CALM2 are associated with QT prolongation and recurrent cardiac arrests in infants.","breadcrumb":{"@id":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/#primaryimage","url":"","contentUrl":""},{"@type":"BreadcrumbList","@id":"https:\/\/johnsonfrancis.org\/professional\/calmodulin-gene-mutation-producing-life-threatening-qt-prolongation\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/johnsonfrancis.org\/professional\/"},{"@type":"ListItem","position":2,"name":"Calmodulin gene mutation producing life threatening QT prolongation"}]},{"@type":"WebSite","@id":"https:\/\/johnsonfrancis.org\/professional\/#website","url":"https:\/\/johnsonfrancis.org\/professional\/","name":"All About Cardiovascular System and Disorders","description":"","publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/johnsonfrancis.org\/professional\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":["Person","Organization"],"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec","name":"Johnson Francis","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","caption":"Johnson Francis"},"logo":{"@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g"},"description":"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal","url":"https:\/\/johnsonfrancis.org\/professional\/author\/jf\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/8034","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/comments?post=8034"}],"version-history":[{"count":0,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/8034\/revisions"}],"wp:attachment":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/media?parent=8034"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/categories?post=8034"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/tags?post=8034"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}