{"id":8066,"date":"2012-05-16T06:21:19","date_gmt":"2012-05-16T12:21:19","guid":{"rendered":"http:\/\/www.cardiophile.net\/?p=8066"},"modified":"2023-05-23T19:57:43","modified_gmt":"2023-05-23T14:27:43","slug":"why-are-statins-taken-at-night","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/","title":{"rendered":"Should You Take Statins at Night?"},"content":{"rendered":"<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/6M7Bptyu2dg\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen=\"\"><\/iframe><\/p>\n<h2><span style=\"color: #008000;\">Should You Take Statins at Night?<\/span><\/h2>\n<p>Statins are drugs like simvastatin and atorvastatin which inhibit cholesterol synthesis by inhibiting the enzyme HMG CoA reductase in the liver. Studies have shown that most cholesterol is synthesised when the dietary intake is at its lowest, typically at night. Thus it was proposed that d<span style=\"font-size: revert; color: initial;\">rugs which inhibit cholesterol synthesis will have better effect when taken at night. This is more so with earlier drugs like lovastatin and simvastatin which were shorter acting than atorvastatin. Studies on simvastatin have documented better effect when taken in the evening than in the morning [1,2]. So it was often advised to take statins at night. As atorvastatin is a long acting drug, it will have its effect even if it is taken at other times of the day. This has also been documented experimentally [3].<\/span><\/p>\n<p><strong><span style=\"color: #0000ff;\">References<\/span><\/strong><\/p>\n<ol>\n<li class=\"citation-text\">Wallace A, Chinn D, Rubin G. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2065035\/\">Taking simvastatin in the morning compared with in the evening: randomised controlled trial<\/a>. BMJ. 2003 Oct 4;327(7418):788. doi: 10.1136\/bmj.327.7418.788. PMID: 14525878; PMCID: PMC214096.<\/li>\n<li>\n<div class=\"citation-text\">Saito Y, Yoshida S, Nakaya N, Hata Y, Goto Y. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2065035\/\">Comparison between morning and evening doses of simvastatin in hyperlipidemic subjects. A double-blind comparative study<\/a>. Arterioscler Thromb. 1991 Jul-Aug;11(4):816-26. doi: 10.1161\/01.atv.11.4.816. PMID: 2065035.<\/div>\n<\/li>\n<li>\n<div class=\"citation-text\">Cilla DD Jr, Gibson DM, Whitfield LR, Sedman AJ. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8844442\/\">Pharmacodynamic effects and pharmacokinetics of atorvastatin after administration to normocholesterolemic subjects in the morning and evening<\/a>. J Clin Pharmacol. 1996 Jul;36(7):604-9. doi: 10.1002\/j.1552-4604.1996.tb04224.x. PMID: 8844442.<\/div>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Statins are drugs like atorvastatin  which inhibits cholesterol synthesis by inhibiting the liver enzyme HMG Co A reductase, which is more active at night.<\/p>\n","protected":false},"author":1,"featured_media":59617,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[11],"tags":[],"class_list":["post-8066","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-heart-disease-faq"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Should You Take Statins at Night? - All About Cardiovascular System and Disorders<\/title>\n<meta name=\"description\" content=\"Statins are drugs like atorvastatin which inhibits cholesterol synthesis by inhibiting the liver enzyme HMG CoA reductase, which is more active at night.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Should You Take Statins at Night? - All About Cardiovascular System and Disorders\" \/>\n<meta property=\"og:description\" content=\"Statins are drugs like atorvastatin which inhibits cholesterol synthesis by inhibiting the liver enzyme HMG CoA reductase, which is more active at night.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/\" \/>\n<meta property=\"og:site_name\" content=\"All About Cardiovascular System and Disorders\" \/>\n<meta property=\"article:published_time\" content=\"2012-05-16T12:21:19+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-23T14:27:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/johnsonfrancis.org\/professional\/wp-content\/uploads\/2012\/05\/Should-You-Take-Statins-at-Night.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"898\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Johnson Francis\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Johnson Francis\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/\"},\"author\":{\"name\":\"Johnson Francis\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"headline\":\"Should You Take Statins at Night?\",\"datePublished\":\"2012-05-16T12:21:19+00:00\",\"dateModified\":\"2023-05-23T14:27:43+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/\"},\"wordCount\":237,\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/wp-content\\\/uploads\\\/2012\\\/05\\\/Should-You-Take-Statins-at-Night.jpg\",\"articleSection\":[\"Heart Disease FAQ\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/\",\"name\":\"Should You Take Statins at Night? - All About Cardiovascular System and Disorders\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/wp-content\\\/uploads\\\/2012\\\/05\\\/Should-You-Take-Statins-at-Night.jpg\",\"datePublished\":\"2012-05-16T12:21:19+00:00\",\"dateModified\":\"2023-05-23T14:27:43+00:00\",\"description\":\"Statins are drugs like atorvastatin which inhibits cholesterol synthesis by inhibiting the liver enzyme HMG CoA reductase, which is more active at night.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/#primaryimage\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/wp-content\\\/uploads\\\/2012\\\/05\\\/Should-You-Take-Statins-at-Night.jpg\",\"contentUrl\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/wp-content\\\/uploads\\\/2012\\\/05\\\/Should-You-Take-Statins-at-Night.jpg\",\"width\":1200,\"height\":898},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/why-are-statins-taken-at-night\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Should You Take Statins at Night?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#website\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/\",\"name\":\"All About Cardiovascular System and Disorders\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/#\\\/schema\\\/person\\\/5441d907049b914770f4bd98fb57feec\",\"name\":\"Johnson Francis\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\",\"caption\":\"Johnson Francis\"},\"logo\":{\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g\"},\"description\":\"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal\",\"url\":\"https:\\\/\\\/johnsonfrancis.org\\\/professional\\\/author\\\/jf\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Should You Take Statins at Night? - All About Cardiovascular System and Disorders","description":"Statins are drugs like atorvastatin which inhibits cholesterol synthesis by inhibiting the liver enzyme HMG CoA reductase, which is more active at night.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/","og_locale":"en_US","og_type":"article","og_title":"Should You Take Statins at Night? - All About Cardiovascular System and Disorders","og_description":"Statins are drugs like atorvastatin which inhibits cholesterol synthesis by inhibiting the liver enzyme HMG CoA reductase, which is more active at night.","og_url":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/","og_site_name":"All About Cardiovascular System and Disorders","article_published_time":"2012-05-16T12:21:19+00:00","article_modified_time":"2023-05-23T14:27:43+00:00","og_image":[{"width":1200,"height":898,"url":"https:\/\/johnsonfrancis.org\/professional\/wp-content\/uploads\/2012\/05\/Should-You-Take-Statins-at-Night.jpg","type":"image\/jpeg"}],"author":"Johnson Francis","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Johnson Francis","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/#article","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/"},"author":{"name":"Johnson Francis","@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"headline":"Should You Take Statins at Night?","datePublished":"2012-05-16T12:21:19+00:00","dateModified":"2023-05-23T14:27:43+00:00","mainEntityOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/"},"wordCount":237,"publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/#primaryimage"},"thumbnailUrl":"https:\/\/johnsonfrancis.org\/professional\/wp-content\/uploads\/2012\/05\/Should-You-Take-Statins-at-Night.jpg","articleSection":["Heart Disease FAQ"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/","url":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/","name":"Should You Take Statins at Night? - All About Cardiovascular System and Disorders","isPartOf":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#website"},"primaryImageOfPage":{"@id":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/#primaryimage"},"image":{"@id":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/#primaryimage"},"thumbnailUrl":"https:\/\/johnsonfrancis.org\/professional\/wp-content\/uploads\/2012\/05\/Should-You-Take-Statins-at-Night.jpg","datePublished":"2012-05-16T12:21:19+00:00","dateModified":"2023-05-23T14:27:43+00:00","description":"Statins are drugs like atorvastatin which inhibits cholesterol synthesis by inhibiting the liver enzyme HMG CoA reductase, which is more active at night.","breadcrumb":{"@id":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/#primaryimage","url":"https:\/\/johnsonfrancis.org\/professional\/wp-content\/uploads\/2012\/05\/Should-You-Take-Statins-at-Night.jpg","contentUrl":"https:\/\/johnsonfrancis.org\/professional\/wp-content\/uploads\/2012\/05\/Should-You-Take-Statins-at-Night.jpg","width":1200,"height":898},{"@type":"BreadcrumbList","@id":"https:\/\/johnsonfrancis.org\/professional\/why-are-statins-taken-at-night\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/johnsonfrancis.org\/professional\/"},{"@type":"ListItem","position":2,"name":"Should You Take Statins at Night?"}]},{"@type":"WebSite","@id":"https:\/\/johnsonfrancis.org\/professional\/#website","url":"https:\/\/johnsonfrancis.org\/professional\/","name":"All About Cardiovascular System and Disorders","description":"","publisher":{"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/johnsonfrancis.org\/professional\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":["Person","Organization"],"@id":"https:\/\/johnsonfrancis.org\/professional\/#\/schema\/person\/5441d907049b914770f4bd98fb57feec","name":"Johnson Francis","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g","caption":"Johnson Francis"},"logo":{"@id":"https:\/\/secure.gravatar.com\/avatar\/80861b82c3f559be9e413245c5643b6c483c93495507facfe32cf96ccd8bcffd?s=96&d=mm&r=g"},"description":"Former Professor of Cardiology, Calicut Govt. Medical Kozhikode, Kerala, India. Editor-in-Chief, BMH Medical Journal","url":"https:\/\/johnsonfrancis.org\/professional\/author\/jf\/"}]}},"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/8066","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/comments?post=8066"}],"version-history":[{"count":5,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/8066\/revisions"}],"predecessor-version":[{"id":59620,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/posts\/8066\/revisions\/59620"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/media\/59617"}],"wp:attachment":[{"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/media?parent=8066"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/categories?post=8066"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/johnsonfrancis.org\/professional\/wp-json\/wp\/v2\/tags?post=8066"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}