{"id":897,"date":"2009-01-27T06:35:40","date_gmt":"2009-01-27T06:35:40","guid":{"rendered":"http:\/\/cardiophile.org\/?p=897"},"modified":"2009-01-27T06:35:40","modified_gmt":"2009-01-27T06:35:40","slug":"circulating-endothelial-cells-proposed-as-new-biomarker-for-irreversible-pulmonary-hypertension-in-congenital-heart-disease","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/circulating-endothelial-cells-proposed-as-new-biomarker-for-irreversible-pulmonary-hypertension-in-congenital-heart-disease\/","title":{"rendered":"Circulating endothelial cells – biomarker for irreversible PAH in CHD"},"content":{"rendered":"

Circulating endothelial cells – biomarker for irreversible PAH in CHD<\/span><\/h2>\n

Circulating endothelial cells – biomarker for irreversible PAH in CHD: David M Smadja, Pascale Gaussem, Laetitia Mauge, Dominique Isra\u00ebl-Biet, Fran\u00e7oise Dignat-George, S\u00e9verine Peyrard, Gabriella Agnoletti, Pascal R Vouh\u00e9, Damien Bonnet and Marilyne L\u00e9vy from Paris Descartes University has suggested that circulating endothelial cells may be a new biomarker for irreversible pulmonary hypertension in congenital heart disease. This is because irreversible pulmonary hypertension in congenital heart disease is associated with endothelial damage and increased circulating endothelial cell count. Surgical lung biopsy specimens in their study showed endothelial remodeling in irreversible pulmonary hypertension but not in reversible pulmonary hypertension. In their study they looked for circulating endothelial cells and circulating progenitor cells in peripheral venous blood, pulmonary arterial blood and pulmonary venous blood of 26 patients. The numbers of circulating progenitor cells were not different between those with reversible and irreversible pulmonary hypertension. But circulating endothelial cells were significantly higher in patients with irreversible pulmonary hypertension. They had a median of 57 cells per milliliter while those with reversible pulmonary hypertension and controls had a median of 3 cells per milliliter.<\/p>\n

Reference<\/strong><\/span><\/p>\n

    \n
  1. David M Smadja, Pascale Gaussem, Laetitia Mauge, Dominique Isra\u00ebl-Biet, Fran\u00e7oise Dignat-George, S\u00e9verine Peyrard, Gabriella Agnoletti, Pascal R Vouh\u00e9, Damien Bonnet, Marilyne L\u00e9vy. Circulating endothelial cells: a new candidate biomarker of irreversible pulmonary hypertension secondary to congenital heart disease<\/a>. Circulation. 2009 Jan 27;119(3):374-81.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Circulating endothelial cells proposed as new biomarker for irreversible pulmonary hypertension in congenital heart disease.<\/p>\n","protected":false},"author":1,"featured_media":37882,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[],"class_list":["post-897","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"yoast_head":"\nCirculating endothelial cells - biomarker for irreversible PAH in CHD<\/title>\n<meta name=\"description\" content=\"Circulating endothelial cells - biomarker for irreversible PAH in CHD: The number of circulating endothelial cells significantly high compared to controls.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/johnsonfrancis.org\/professional\/circulating-endothelial-cells-proposed-as-new-biomarker-for-irreversible-pulmonary-hypertension-in-congenital-heart-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Circulating endothelial cells - 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