{"id":9844,"date":"2008-12-21T03:43:21","date_gmt":"2008-12-21T03:43:21","guid":{"rendered":"http:\/\/cardiophile.org\/?p=818"},"modified":"2008-12-21T03:43:21","modified_gmt":"2008-12-21T03:43:21","slug":"bosentan-decreased-pulmonary-vascular-resistance-in-inoperable-cteph","status":"publish","type":"post","link":"https:\/\/johnsonfrancis.org\/professional\/bosentan-decreased-pulmonary-vascular-resistance-in-inoperable-cteph\/","title":{"rendered":"Bosentan decreased pulmonary vascular resistance in inoperable CTEPH"},"content":{"rendered":"

Bosentan decreased pulmonary vascular resistance in inoperable CTEPH<\/span><\/h2>\n

Bosentan decreased pulmonary vascular resistance in inoperable chronIc thromboembolic pulmonary hypertension (CTEPH): Bosentan is a drug which is effective for primary pulmonary hypertension. Xavier Ja\u00efs 1, Andrea M D’Armini, Pavel Jansa, Adam Torbicki, Marion Delcroix, Hossein A Ghofrani, Marius M Hoeper, Irene M Lang, Eckhard Mayer, Joanna Pepke-Zaba, Lo\u00efc Perchenet, Adele Morganti, G\u00e9rald Simonneau and Lewis J Rubin, the Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension Study Group published the results of BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a Randomized, Placebo-Controlled Trial in the of Journal of American College of Cardiology [1]. 157 patients participated in the trial and they were randomized to bosentan or placebo for 16 weeks. Pulmonary vascular resistance (PVR) was reduced and the cardiac index improved in the bosentan treated group, but the 6-minute walk distance did not improve. Further trials are needed to assess whether the improved pulmonary vascular resistance will translate into long term clinical benefits. Bosentan treatment was well-tolerated and appears promising for patients with chronic thromboembolic pulmonary hypertension.<\/p>\n

Reference<\/strong><\/span><\/p>\n

    \n
  1. Xavier Ja\u00efs, Andrea M D’Armini, Pavel Jansa, Adam Torbicki, Marion Delcroix, Hossein A Ghofrani, Marius M Hoeper, Irene M Lang, Eckhard Mayer, Joanna Pepke-Zaba, Lo\u00efc Perchenet, Adele Morganti, G\u00e9rald Simonneau, Lewis J Rubin, Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension Study Group. Bosentan for treatment of inoperable chronic thromboembolic pulmonary hypertension: BENEFiT (Bosentan Effects in iNopErable Forms of chronIc Thromboembolic pulmonary hypertension), a randomized, placebo-controlled trial<\/a>. J Am Coll Cardiol. 2008 Dec 16;52(25):2127-34.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Bosentan decreased pulmonary vascular resistance and improved the cardiac index, but not the 6 minute walk distance.<\/p>\n","protected":false},"author":1,"featured_media":37933,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","footnotes":""},"categories":[9],"tags":[550,766,1001],"class_list":["post-9844","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general","tag-bosentan","tag-chronic-thromboembolic-pulmonary-hypertension","tag-cteph"],"yoast_head":"\nBosentan decreased pulmonary vascular resistance in inoperable CTEPH<\/title>\n<meta name=\"description\" content=\"Bosentan decreased pulmonary vascular resistance in inoperable CTEPH and improved the cardiac index, but not the 6 minute walk distance.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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