Is there any interaction between amiodarone and digoxin?

Is there any interaction between amiodarone and digoxin?

Amiodarone increases the serum concentration of digoxin by decreasing both renal and nonrenal clearance of digoxin. Hence the dose of digoxin may have to be reduced when amiodarone is added.

References

  1. Nademanee K, Kannan R, Hendrickson J, Ookhtens M, Kay I, Singh BN. Amiodarone-digoxin interaction: clinical significance, time course of development, potential pharmacokinetic mechanisms and therapeutic implications. J Am Coll Cardiol. 1984 Jul;4(1):111-6. doi: 10.1016/s0735-1097(84)80327-7. PMID: 6736437.
  2. Fenster PE, White NW Jr, Hanson CD. Pharmacokinetic evaluation of the digoxin-amiodarone interaction. J Am Coll Cardiol. 1985 Jan;5(1):108-12. doi: 10.1016/s0735-1097(85)80091-7. PMID: 3964797.