Can Heparin be Prothrombotic?

Can heparin be prothrombotic?

Unfractionated heparin can theoretically make platelets more reactive to activation by other platelet function agonists such as adenosine diphosphate. Heparin can bind to Glycoprotein IIb/IIIa receptor on the platelet resulting in a prothrombotic effect. For these reasons, it may not be ideal to bridge with heparin while interrupting anti-platelet agents prior to surgery, unless there are other reasons for giving heparin.