Coffee consumption decreases the chance of type 2 diabetes mellitus

Coffee consumption decreases the chance of type 2 diabetes mellitus

The relation between coffee and diabetes has been evaluated in multiple cohort studies. A systematic review of nine cohort studies with nearly two hundred thousand participants and over eight thousand new cases of type 2 diabetes mellitus supports the hypothesis that habitual coffee consumption is associated with significant lowering of the risk for type 2 diabetes mellitus [1].

The risk was lowest in those who drank more than 6 cups of coffee per day. It may be related to long term preservation of liver and beta cell function. Improved fat oxidation in liver lowers the risk of steatosis. Preservation of functional beta cell mass is mediated by enhanced mitochondrial function, lower endoplasmic reticulum stress and prevention or clearance of aggregates of misfolded proinsulin or amylin [2].

References

1. van Dam RM, Hu FB. Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA. 2005;294:97-104.
2. Kolb H, Martin S, Kempf K. Coffee and Lower Risk of Type 2 Diabetes: Arguments for a Causal Relationship. Nutrients. 2021 Mar 31;13(4):1144. doi: 10.3390/nu13041144. PMID: 33807132; PMCID: PMC8066601.