Criticism of MADIT Trials

Beta blocker use was more in the ICD arm than conventional therapy arm, which could have contributed to the better results in the ICD. This criticism was taken care of by MADIT II trial which showed that just the presence of a low ejection fraction following myocardial infarction was enough to implant a defibrillator. But some clinicians believe that this may not be true, considering the large number of patients requiring ICD implantation in this setting.

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