Effect of Sacubitril/valsartan on natriuretic peptides – Cardiology MCQ

a) Decrease in BNP and NT-proBNP

b) Increase in BNP and NT-proBNP

c) Increase in BNP and decrease in NT-proBNP

d) Decrease in BNP and increase in NT-proBNP

Both BNP and NT-proBNP are natriuretic peptides which are increased in heart failure. Angiotensin receptor neprilysin inhibitor (ARNI) Sacubitril/Valsartan improves heart heart failure and thereby decreases NT-proBNP levels. But by way of neprilysin inhibition, degradation of BNP is reduced and BNP level tends to rise [1]

1. Zile MR et al. Prognostic Implications of Changes in N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Heart Failure. J Am Coll Cardiol. 2016;68(22):2425-2436.