Familial atrial fibrillation

Familial atrial fibrillation

Eighteen types of familial atrial fibrillation (AF) has been described in the OMIM (Online Mendelian Inheritance in Man) database.

One of the early reports identifying a genetic locus for familial AF was by R Brugada, T Tapscott, G Z Czernuszewicz, A J Marian, A Iglesias, L Mont, J Brugada, J Girona, A Domingo, L L Bachinski and R Roberts [1], in which ten members spanning over three generations had an autosomal dominant pattern. Nine of them had chronic atrial fibrillation while one had paroxysmal atrial fibrillation.

It may be noted that gene for ATFB16 is same as that for BRGA7. That for ATFB17 is the same as that for LQT10. These are heterozygous mutations.

Reference

1. R Brugada, T Tapscott, G Z Czernuszewicz, A J Marian, A Iglesias, L Mont, J Brugada, J Girona, A Domingo, L L Bachinski, R Roberts. Identification of a genetic locus for familial atrial fibrillation. N Engl J Med. 1997 Mar 27;336(13):905-11.