Faster degeneration of bioprosthetic valves in diabetics

Faster degeneration of bioprosthetic valves in diabetics

Faster degeneration of bioprosthetic valves in diabetics: A study involving twelve centers between 1988 and 2009 by Roberto Lorusso, Sandro Gelsomino, Fabiana Lucà, Giuseppe De Cicco, Giuseppe Billè, Rocco Carella, Emmanuel Villa, Gianni Troise, Mario Viganò, Carlo Banfi, Carmine Gazzaruso, Pier Gagliardotto, Lorenzo Menicanti, Francesco Formica, Giovanni Paolini, Stefano Benussi, Ottavio Alfieri, Matteo Pastore, Sandro Ferrarese, Giovanni Mariscalco, Germano Di Credico, Cristian Leva, Claudio Russo, Aldo Cannata, Roberto Trevisan, Ugolino Livi, Roberto Scrofani, Carlo Antona, Andrea Sala, Gian Franco Gensini, Jos Maessen and Andrea Giustina [1] has found that degeneration of bioprosthetic valves is faster in patients with type 2 diabetes mellitus.

There were about six thousand and two hundred patients the database analyzed, of which over one thousand and seven hundred were having type 2 diabetes mellitus. Propensity score matching algorithm was used to match 1113 patients with type 2 diabetes mellitus with the same number of those without diabetes mellitus. The one month mortality was 7.8 percent in diabetics while it was only 2.9 percent in the non diabetics. Seven year freedom from valve deterioration was 95.4 percent in the non diabetics while its was only 73.2 percent in diabetics. Diabetes mellitus was found to be the strongest predictor for structural valve degeneration with a hazard ratio of 2.39. This association was found even after adjusting for other important risk factors.

Reference

  1. Roberto Lorusso, Sandro Gelsomino, Fabiana Lucà, Giuseppe De Cicco, Giuseppe Billè, Rocco Carella, Emmanuel Villa, Gianni Troise, Mario Viganò, Carlo Banfi, Carmine Gazzaruso, Pier Gagliardotto, Lorenzo Menicanti, Francesco Formica, Giovanni Paolini, Stefano Benussi, Ottavio Alfieri, Matteo Pastore, Sandro Ferrarese, Giovanni Mariscalco, Germano Di Credico, Cristian Leva, Claudio Russo, Aldo Cannata, Roberto Trevisan, Ugolino Livi, Roberto Scrofani, Carlo Antona, Andrea Sala, Gian Franco Gensini, Jos Maessen, Andrea Giustina. Type 2 Diabetes Mellitus Is Associated With Faster Degeneration of Bioprosthetic Valve: Results From a Propensity Score-Matched Italian Multicenter Study. Circulation. 2012 Jan 31;125(4):604-14.