GI bleed with Continuous flow LVAD – Mechanisms Prof. Dr. Johnson Francis | April 13, 2019 | Cardiac Surgery | 1 Comment GI bleed with Continuous flow LVAD – Mechanisms Gastrointestinal bleeds can occur in 15-40% of patients on continuous flow left ventricular assist devices (LVAD) for end stage heart failure. Proposed mechanisms for gastrointestinal bleeds with continuous flow LVAD includes: Acquired von Willebrand disease Impaired platelet aggregation Enhanced angiogenesis causing arteriovenous malformations (AVM) Intensity of anticoagulation AVMs may contribute to about half of the GI bleed with continuous flow LVADS. Hypoperfusion of gastrointestinal mucosa leads to angiogenesis and the new friable vessels are prone for bleeding . Reference Guha A, Eshelbrenner CL, Richards DM, Monsour HP Jr. Gastrointestinal bleeding after continuous-flow left ventricular device implantation: review of pathophysiology and management. Methodist Debakey Cardiovasc J. 2015 Jan-Mar;11(1):24-7. Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related Posts Intramural VSD No Comments | Oct 18, 2015 Mechanisms of AR in operated tetralogy of Fallot No Comments | Jul 17, 2011 Patient – prosthesis mismatch in AVR No Comments | Jul 30, 2014 No difference in survival with tissue valve in dialysis patients with endocarditis No Comments | Jul 28, 2013 One Comment Rahul April 13, 2019 Enhanced angiogenesis forming av fistula Add a Comment Cancel replyYou must be logged in to post a comment.