How Does Fever Precipitate Arrhythmia in Brugada Syndrome?

How Does Fever Precipitate Arrhythmia in Brugada Syndrome?

In Brugada syndrome dysfunctional voltage gated sodium channels Na_V1.5 have delayed activation and earlier inactivation. This leads to shortening of action potential duration. There is additional shortening of action potential duration at higher temperatures. This is the proposed mechanism of precipitation of arrhythmias in Brugada syndrome during febrile episodes. That is why prompt treatment of fever is an important preventive strategy to be deployed in those with Brugada syndrome.

Reference

1. Krahn AD, Behr ER, Hamilton R, Probst V, Laksman Z, Han HC. Brugada Syndrome. JACC Clin Electrophysiol. 2022 Mar;8(3):386-405. doi: 10.1016/j.jacep.2021.12.001. PMID: 35331438.